Journal ArticleDOI
The influence of surface active l-leucine and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) in the improvement of aerosolization of pyrazinamide and moxifloxacin co-spray dried powders.
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TLDR
The differences in the aerosolization behaviours of the pyrazinamide and moxifloxacin spray dried powders with and without excipients was a combination of difference in the surface morphology and surface composition.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2018-05-05. It has received 35 citations till now. The article focuses on the topics: Aerosolization & Spray drying.read more
Citations
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Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches.
TL;DR: This review is focused on introducing critical formulation and processing factors in spray drying of small molecule drugs and large biomolecules, their similarities and differences and provides an overview of the experimental optimisation strategies designed to achieve optimum spray drying results in the shortest possible timeframe while utilising minimum product.
Journal ArticleDOI
Physical stability of dry powder inhaler formulations
TL;DR: This review focuses on the impact of solid-state stability on aerosolization performance of DPI drug particles manufactured by powder production approaches and particle-engineering techniques and highlights the different analytical tools that can be used to characterize the physical instability originating from production and storage.
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The wound healing and antibacterial potential of triple-component nanocomposite (chitosan-silver-sericin) films loaded with moxifloxacin
TL;DR: The prepared films indicated a remarkable wound healing applications with successful fibrosis, collagen reorganization, neovascularization, and mild epidermal regeneration after 7 days of treatment with no silver ions detection in animal's blood.
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Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties
TL;DR: In this article, the authors discuss various aspects of spray drying such as configurations and functions, drying kinetics, component distribution and particle solidification, and the functionality and behavior of excipients during drying.
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Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection
Basanth Babu Eedara,Wafaa Alabsi,David Encinas-Basurto,Robin Polt,Julie G. Ledford,Heidi M. Mansour +5 more
TL;DR: In this paper, the authors present possible inhaled therapeutics and vaccines for the treatment of COVID-19 symptoms, which is caused by coronavirus-2 (SARS-CoV-2) and has produced a global pandemic.
References
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Journal ArticleDOI
Pharmaceutical particle engineering via spray drying.
TL;DR: A classification based on dimensionless numbers is presented that can be used to estimate how excipient properties in combination with process parameters influence the morphology of the engineered particles.
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Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance
TL;DR: The incorporation of lactose, albumin and DPPC in the formulation all improved the aerosolization properties, in contrast to trehalose and the mannitol which decreased powder flowability.
Journal ArticleDOI
The morphology of spray-dried particles
D.E. Walton,C.J. Mumford +1 more
TL;DR: In this article, single particles were produced in a convective drying process analogous to spray drying, in which, different solids or mixtures of solids were dried from solutions, slurries or pastes as single suspended droplets.
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Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: manufacture and characterization.
P O'Hara,Anthony J. Hickey +1 more
TL;DR: Respirable rifampicin loaded PLGAmicrospheres were produced by both solvent evaporation and spray drying methods, and were evaluated in an animal model oftuberculosis.
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Feret‘s Statistical Diameter as a Measure of Particle Size
TL;DR: The diameter of the circle of equal area has been used to measure the size of irregularly shaped particles in profile under the microscope as discussed by the authors, and has been shown to be a good measure of the shape and hydrodynamical properties of particles.