The lactococcal lmrp gene encodes a proton motive force-dependent drug transporter
Henk Bolhuis,Gerrit J. Poelarends,HW van Veen,Berend Poolman,Arnold J. M. Driessen,Wil N. Konings +5 more
TLDR
Results indicate that in the absence of the functional drug-proton antiporter LmrP, L. lactis is able to overexpress another, ATP-dependent, drug extrusion system, and substantiate earlier studies on the isolation and characterization of drug-resistant mutants of L. latis.About:
This article is published in Journal of Biological Chemistry.The article was published on 1995-11-03 and is currently open access. It has received 132 citations till now. The article focuses on the topics: Lactococcus lactis & Bicyclomycin.read more
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Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems
TL;DR: The availability of an increasing number of high-resolution structures has provided a valuable framework for interpretation of recent studies, and realistic models have been proposed to explain how these fascinating molecular machines use complex dynamic processes to fulfill their numerous biological functions.
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Efflux-Mediated Drug Resistance in Bacteria
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: Fluoroquinolones and β-lactams of the latest generations are likely to select for overproduction mutants of these pumps and make the bacteria resistant in one step to practically all classes of antibacterial agents.
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Proton-dependent multidrug efflux systems.
TL;DR: Whether the normal physiological role of the multidrug efflux systems is to protect the cell from toxic compounds or whether they fulfil primary functions unrelated to drug resistance and only efflux multiple drugs fortuitously or opportunistically is discussed.
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Molecular Properties of Bacterial Multidrug Transporters
TL;DR: Kinetic analysis of drug transport by multidrug transporters provided evidence that these proteins may contain multiple substrate-binding sites, and these proteins are capable of mediating the export of structurally unrelated drugs independent of accessory proteins or cytoplasmic components.
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Antibiotic resistance in food lactic acid bacteria--a review.
Shalini Mathur,Rameshwar Singh +1 more
TL;DR: A number of initiatives have been recently launched by various organizations across the globe to address the biosafety concerns of starter cultures and probiotic microorganisms to lead to better understanding of the role played by the dairy starter microorganisms in horizontal transfer of antibiotic resistance genes to intestinal microorganisms and food-associated pathogenic bacteria.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Journal ArticleDOI
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.