The mouse genome contains two nonallelic pro-opiomelanocortin genes.
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It is reported here that the mouse genome contains two POMC related gene sequences, alpha- and beta-POMC, that alpha-PomC is located on mouse chromosome 12 while beta-pOMC is on a different chromosome, probably chromosome 19.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-08-10 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Gene & Pseudogene.read more
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Journal ArticleDOI
Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress
TL;DR: Cutaneous expression of the CRH/POMC system is highly organized, encoding mediators and receptors similar to the hypothalamic-pituitary-adrenal (HPA) axis, that in the skin is expressed as a highly localized response which neutralizes noxious stimuli and attendant immune reactions.
Journal ArticleDOI
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
TL;DR: A recombinant vaccinia virus vector was used to coexpress the two candidate mouse prohormone convertases, PC1 and PC2, together with mouse proopiomelanocortin in the constitutively secreting cell line BSC-40 and in the endocrine tissue-derived cell lines PC12 and AtT-20, which exhibit regulated secretion.
Book ChapterDOI
The Origin and Evolution of Retroposons
TL;DR: This chapter describes the origin and evolution of retroposons, a class of dispersed sequences in DNA which appear to have arisen during evolution by a particular mechanism of inserting RNA sequences into chromosomal DNA (retroposition).
Journal ArticleDOI
Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.
Mark L. Watson,Jaya K. Rao,Gary S. Gilkeson,Philip Ruiz,Eva M. Eicher,David S. Pisetsky,Akio Matsuzawa,Julie M. Rochelle,Michael F. Seldin +8 more
TL;DR: The results suggest that altered Fas transcription results in the failure of lymphocytes to undergo programmed cell death and may lead to an altered immune cell repertoire, which may explain certain central and peripheral defects in tolerance that are present in autoimmune disease.
Journal ArticleDOI
In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.
TL;DR: Data demonstrate distinctive patterns of expression for each of the major anterior pituitary hormone genes during development of the mouse Pituitary gland and suggest that different groups of committed cells are the immediate precursors to the terminally differentiated hormone-secreting cell types.
References
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Detection of specific sequences among DNA fragments separated by gel electrophoresis.
TL;DR: This paper describes a method of transferring fragments of DNA from agarose gels to cellulose nitrate filters that can be hybridized to radioactive RNA and hybrids detected by radioautography or fluorography.
Journal ArticleDOI
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
TL;DR: Labeled DNAs (and restriction endonuclease fragments derived from them) are useful probes for detecting rare homologous sequences by in situ hybridization and reassociation kinetic analysis.
Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
Journal ArticleDOI
3′ Non-coding region sequences in eukaryotic messenger RNA
TL;DR: A large selection of the 3′ non-coding regions of rabbit and human globin mRN As are 85% homologous, demonstrating that this region is significantly conserved in evolution.
Journal ArticleDOI
Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor.
Shigetada Nakanishi,Akira Inoue,Toru Kita,Masahiro Nakamura,Annie C. Y. Chang,Stanley N. Cohen,Shosaku Numa +6 more
TL;DR: The nucleotide sequence of a 1,091-base pair cloned cDNA insert encoding bovine corticotropin-β-lipotropin precursor mRNA indicates that the precursor protein consists of repetitive units and includes a third melanotropin sequence in its cryptic portion.
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