Journal ArticleDOI
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation
TLDR
The role of monocytes/macrophages and neutrophils in Atherosclerosis is described, mechanisms of activation of the NLRP3 inflammasome in the setting of atherosclerosis-associated inflammation are outlined and potential therapies that specifically target the NL RP3 infammasome and/or its downstream mediators in atheros sclerosis are discussed.About:
This article is published in Atherosclerosis.The article was published on 2017-12-01. It has received 198 citations till now. The article focuses on the topics: Inflammasome & Inflammation.read more
Citations
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Journal ArticleDOI
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Patricia Marchio,Sol Guerra-Ojeda,José M. Vila,Martin Aldasoro,Victor M. Victor,María Dolores Mauricio +5 more
TL;DR: Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment.
Journal ArticleDOI
The role of inflammasomes in kidney disease.
Takanori Komada,Daniel A. Muruve +1 more
TL;DR: Findings in experimental models of kidney disease suggest that small-molecule inhibitors targeting NLRP3 and other inflammasome components are promising therapeutic agents and may provide new therapeutic strategies for kidney disease.
Journal ArticleDOI
Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review.
TL;DR: An update on CBSIs reported in the past three years is provided and the clinical status of CBSIs is discussed, likely that efforts will continue to develop CBSIs for a diverse set of cancers.
Journal ArticleDOI
Colchicine in Patients With Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial.
David C. Tong,Stephen Quinn,Arthur Nasis,C. Hiew,Philip Roberts-Thomson,Heath Adams,Rumes Sriamareswaran,Nay M. Htun,William Wilson,Dion Stub,William J. van Gaal,Laurie Howes,Nicholas Collins,Andy S.C. Yong,Ravinay Bhindi,Robert Whitbourn,Astin Lee,Chris Hengel,Kaleab N Asrress,Melanie Freeman,John Amerena,Andrew Wilson,Jamie Layland,Jamie Layland +23 more
TL;DR: Colchicine, a commonly used treatment for gout, has recently emerged as a treatment for acute coronary syndromes, and its role in clinical manifestations and complications is still under investigation.
Journal ArticleDOI
Anti-inflammatory therapy for COVID-19 infection: the case for colchicine.
Aaron Z Reyes,Kelly A Hu,Jacob Teperman,Theresa Wampler Muskardin,Jean-Claude Tardif,Binita Shah,Michael H. Pillinger +6 more
TL;DR: Colchicine is easily administered, generally well tolerated and inexpensive, and holds particular promise to reduce the risk of hospitalisation and mortality due to COVID-19 in the outpatient setting, to the benefit of both resource-replete and resource-poor regions.
References
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Journal ArticleDOI
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Paul M. Ridker,Brendan M. Everett,Tom Thuren,Jean G. MacFadyen,William Chang,Christie M. Ballantyne,Francisco H. Fonseca,Jose C. Nicolau,Wolfgang Koenig,Stefan D. Anker,John J.P. Kastelein,Jan H. Cornel,Prem Pais,Daniel Pella,Jacques Genest,Renata Cifkova,Alberto J. Lorenzatti,Tamás Forster,Zhanna Kobalava,Luminita Vida-Simiti,Marcus Flather,Hiroaki Shimokawa,Hisao Ogawa,Mikael Dellborg,Paulo Roberto Ferreira Rossi,Roland P.T. Troquay,Peter Libby,Robert J. Glynn +27 more
TL;DR: Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Journal ArticleDOI
Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren +25 more
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.
Journal ArticleDOI
The pathogenesis of atherosclerosis (first of two parts).
Russell Ross,John A. Glomset +1 more
Journal ArticleDOI
Immunological and Inflammatory Functions of the Interleukin-1 Family
TL;DR: The IL-1 family includes members that suppress inflammation, both specifically within the IL-2 family but also nonspecifically for TLR ligands and the innate immune response.
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