The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
P Menu,James E Vince +1 more
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TLDR
Recently, inflammasome function has been implicated in more common human conditions, which raises the possibility that anti‐IL‐1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammaome activity.Abstract:
While interleukin (IL)-1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL-1β activating platforms, known as inflammasomes, can assemble in response to the detection of endogenous host and pathogen-associated danger molecules. Formation of these protein complexes results in the autocatalysis and activation of caspase-1, which processes precursor IL-1β into its secreted biologically active form. Inflammasome and IL-1β activity is required to efficiently control viral, bacterial and fungal pathogen infections. Conversely, excess IL-1β activity contributes to human disease, and its inhibition has proved therapeutically beneficial in the treatment of a spectrum of serious, yet relatively rare, heritable inflammasomopathies. Recently, inflammasome function has been implicated in more common human conditions, such as gout, type II diabetes and cancer. This raises the possibility that anti-IL-1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammasome activity.read more
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Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages
Michiel Maurits Kroes,Rob Mariman,Daniëlle Hijdra,Hendrik-Jan Hamstra,Karlijn J. W. M. van Boxtel,Jos P. M. van Putten,Jelle de Wit,Elena Pinelli +7 more
TL;DR: It is demonstrated that B. pertussis induces inflammasome activation in human macrophages and that the IL-18 produced by these cells is required for the activation of human NK cells, which in turn enhances the pro-inflammatory response to this pathogen.
Journal ArticleDOI
Programmed cell death in Legionella infection.
TL;DR: Understanding how different forms of programmed cell death contribute to Legionella infectivity and are manipulated by Legionella effector proteins will be important for identifying novel antibacterial therapeutic targets.
Journal ArticleDOI
NLRP3 Inflammasome Activation: A Therapeutic Target for Cerebral Ischemia–Reperfusion Injury
TL;DR: The assembly and activation of NLRP3 inflammasome lead to the caspase-1-dependent release of pro-inflammatory cytokines, such as interleukin (IL)-1β and IL-18, and pyroptosis is a pro- inflammatory cell death that occurs in a dependent manner on NLRP2 inflammaome after cerebral I/R injury.
Journal ArticleDOI
Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation.
Tomohiko Murakami,Lerdluck Ruengsinpinya,Eriko Nakamura,Yoshifumi Takahata,Kenji Hata,Hiroaki Okae,Shun'ichiro Taniguchi,Masafumi Takahashi,Riko Nishimura +8 more
TL;DR: G protein subunit β 1 (GNB1), a downstream molecule of G protein–coupled receptors (GPCRs), which regulates the NLRP3 inflammasome activation is identified, and it provides a regulatory mechanism of the NL RP3 infammasome.
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Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats
TL;DR: Electroacupuncture pretreatment attenuates inflammatory lung injury after CPB by suppressing NLRP3 inflammasome activation and inhibited IL-1β release into the serum and BALF afterCPB.
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