The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
P Menu,James E Vince +1 more
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TLDR
Recently, inflammasome function has been implicated in more common human conditions, which raises the possibility that anti‐IL‐1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammaome activity.Abstract:
While interleukin (IL)-1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL-1β activating platforms, known as inflammasomes, can assemble in response to the detection of endogenous host and pathogen-associated danger molecules. Formation of these protein complexes results in the autocatalysis and activation of caspase-1, which processes precursor IL-1β into its secreted biologically active form. Inflammasome and IL-1β activity is required to efficiently control viral, bacterial and fungal pathogen infections. Conversely, excess IL-1β activity contributes to human disease, and its inhibition has proved therapeutically beneficial in the treatment of a spectrum of serious, yet relatively rare, heritable inflammasomopathies. Recently, inflammasome function has been implicated in more common human conditions, such as gout, type II diabetes and cancer. This raises the possibility that anti-IL-1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammasome activity.read more
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Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways
TL;DR: By inhibiting the activities of inflammasomes in glial cells, neuronal loss was partially prevented by suppressing the apoptosis in the brains of ICH mice, protecting them from neurological defects.
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PRAK Promotes the Pathogen Clearance by Macrophage Through Regulating Autophagy and Inflammasome Activation.
TL;DR: In this article, the p38 regulated/activated protein kinase (PRAK) was found to contribute to the clearance of intracellular pathogens by affecting multiple aspects of the macrophage function.
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Role of Pyroptosis, a Pro-inflammatory Programmed Cell Death, in Epilepsy
TL;DR: Since the involvement of pyroptosis in the development of epilepsy has been established, pyroPTosis-targeted therapies may represent a novel anti-epileptogenic strategy.
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The NLRP3 inflammasome mediates liver failure by activating procaspase-1 and pro-IL-1 β and regulating downstream CD40-CD40L signaling.
Zenghui Li,Jianning Jiang +1 more
TL;DR: In this paper, the regulatory roles of the NLRP3 inflammasome in hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) were explored.
Journal ArticleDOI
Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia.
Joyce de Cassia Rosa de Jesus,Ariene Soares de Pinho Murari,Katrin Radloff,Ruan Carlos Macêdo de Moraes,Raquel Galvão Figuerêdo,Ana Flávia Marçal Pessoa,José Cesar Rosa-Neto,Emidio Marques de Matos-Neto,Paulo Sérgio Martins de Alcântara,Flavio Tokeshi,Linda Ferreira Maximiano,Fang Chia Bin,Fernanda Bellotti Formiga,José Pinhata Otoch,Marilia Seelaender +14 more
TL;DR: In this paper, the activation of the NLRP3 inflammasome pathway in two adipose tissue depots obtained from patients with colorectal cancer and compared with that another inflammatory pathway, NF-κB, was examined.
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