The NLRP3 inflammasome in health and disease: the good, the bad and the ugly
P Menu,James E Vince +1 more
TLDR
Recently, inflammasome function has been implicated in more common human conditions, which raises the possibility that anti‐IL‐1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammaome activity.Abstract:
While interleukin (IL)-1β plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. Large IL-1β activating platforms, known as inflammasomes, can assemble in response to the detection of endogenous host and pathogen-associated danger molecules. Formation of these protein complexes results in the autocatalysis and activation of caspase-1, which processes precursor IL-1β into its secreted biologically active form. Inflammasome and IL-1β activity is required to efficiently control viral, bacterial and fungal pathogen infections. Conversely, excess IL-1β activity contributes to human disease, and its inhibition has proved therapeutically beneficial in the treatment of a spectrum of serious, yet relatively rare, heritable inflammasomopathies. Recently, inflammasome function has been implicated in more common human conditions, such as gout, type II diabetes and cancer. This raises the possibility that anti-IL-1 therapeutics may have broader applications than anticipated previously, and may be utilized across diverse disease states that are linked insidiously through unwanted or heightened inflammasome activity.read more
Citations
More filters
Journal ArticleDOI
Role of Pyroptosis in Traumatic Brain and Spinal Cord Injuries.
Xinli Hu,Huanwen Chen,Hui Xu,Yaosen Wu,Chenyu Wu,Chang Jia,Yao Li,Sunren Sheng,Cong Xu,Huazi Xu,Wen-Fei Ni,Kailiang Zhou +11 more
TL;DR: Current knowledge on how pyroptosis is involved in CNS injuries is discussed, focusing on new discoveries regarding how pyproptosis activation occurs, differences between CNS cell types following injury, time-course of inflammatory responses, and key regulatory steps of pyroPTosis.
Journal ArticleDOI
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
TL;DR: In this paper, the authors summarized recent efforts to develop therapeutic applications targeting the NLRP3 inflammasome to cure and prevent chronic inflammatory diseases and provided beneficial information on the design of therapeutic strategies for NLRP-related diseases.
Journal ArticleDOI
The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity
Özlem Yilmaz,Kyulim Lee +1 more
TL;DR: This review outlines the major components of the known inflammasome complexes/mechanisms and highlights their regulation, in particular, by oral microorganisms, in relation to periodontal disease pathology.
Journal ArticleDOI
NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis
TL;DR: The synovial NLRP3 expression increased at the early onset of RA, and the expression level was correlated with the clinical arthritis severity and extent of radiological destruction, suggesting thatNLRP3 is involved in the pathogenesis of RA.
Journal ArticleDOI
Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex.
Xiaoxin Liu,Chao Liu +1 more
TL;DR: It is confirmed that baicalin has antidepressant effect and its mechanisms likely related to the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex in the CUMS model of depression.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2002.
TL;DR: There are striking variations in the risk of different cancers by geographic area, most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.
Journal ArticleDOI
Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.