The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse
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TLDR
A semi-quantitative scoring system that can be applied universally to instability, enzymatic, transgenic and spontaneous OA models may be a useful tool for both new and experienced scorers to sensitively evaluate models and OA mechanisms, and also provide a common paradigm for comparative evaluation across the many groups performing these analyses.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2010-10-01 and is currently open access. It has received 1701 citations till now.read more
Citations
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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok-Hee Jeon,Chaekyu Kim,Chaekyu Kim,Remi-Martin Laberge,Marco Demaria,Marco Demaria,Sona Rathod,Alain Philippe Vasserot,Jae Wook Chung,Do Hun Kim,Yan Poon,Nathaniel David,Darren J. Baker,Jan M. van Deursen,Judith Campisi,Judith Campisi,Jennifer H. Elisseeff +16 more
TL;DR: It is found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development, which support the use of SnCs as a therapeutic target for treating degenerative joint disease.
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Osteoarthritis: toward a comprehensive understanding of pathological mechanism.
TL;DR: A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.
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Principles for Valid Histopathologic Scoring in Research
TL;DR: Understanding key principles of tissue scoring can help in the development and/or optimization of scoring systems so as to consistently yield meaningful and valid scoring data.
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Animal models of osteoarthritis: classification, update, and measurement of outcomes.
TL;DR: This review summarizes the current understanding of the disease pathogenesis, invasive and non-invasive animal models, imaging modalities, and pain assessment techniques in the animals.
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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.
TL;DR: Understanding how the chondrocytes in adult human cartilage undergo phenotypic modulation and promote matrix destruction and abnormal repair in OA may to lead to identification of critical targets for therapy to block cartilage damage and promote effective cartilage repair.
References
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Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
A. Michael Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,Pierre J. Meunier,Susan M. Ott,Robert R. Recker +7 more
TL;DR: A committee of the Society to develop a unified system of termnology, suitable for adoption by the Journal of Bone and Mineral Research as part of its Instructions to Authors is formed, and is as complex and conceptually difficult as the field with which it deals.
Journal Article
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
A. M. Parfitt,Marc K. Drezner,Francis H. Glorieux,John A. Kanis,Hartmut H. Malluche,P. J. Meunier,Susan M. Ott,Robert R. Recker +7 more
Journal ArticleDOI
The etiology of chondromalacia patellae
TL;DR: Rubbing of the medial patellar facet on the rim at the upper border of the lateral femoral condyle can explain in part the etiology of chondromalacia.
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Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.
TL;DR: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo -arthritic process.
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Osteoarthritis cartilage histopathology: grading and staging
Kenneth P.H. Pritzker,Kenneth P.H. Pritzker,Sergio A. Jimenez,Keld Ostergaard,J.-P. Pelletier,P A Revell,Donald Salter,W.B. van den Berg +7 more
TL;DR: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply as discussed by the authors, however, further studies are required to confirm the system's utility, as well as their reproducibility and validity.