Journal ArticleDOI
The peopling of Sardinia (Italy): history and effects
TLDR
From work performed at different levels on genetic structure analysis there emerges an extremely complex picture of the relationships between Sardinian and other Italian and Mediterranean populations, but also of relationships within the Sardinian population itself.Abstract:
Over the last ten years the population of the Mediterranean island of Sardinia has been object of numerous studies in the fields of anthropology and population genetics. Its insularity, central position in the Mediterranean area and rich historical past have made the island a veritable laboratory for the study and understanding of those interacting evolutionary mechanisms which determine a population's genetic structure. Indeed, from work performed at different levels on genetic structure analysis there emerges an extremely complex picture of the relationships between Sardinian and other Italian and Mediterranean populations, but also of relationships within the Sardinian population itself The diversification from Mediterranean and Italian populations can be explained by Sardinia's historical and demographic past. Internal heterogeneity can be attributed, in part, to strict isolation and the accompanying high levels of endogamy and inbreeding, and in part to the endemic presence of malaria which exerted a strong selective pressure on some characteristics; determining, for example, the differentiation between the plains and the mountain areas. Finally, an influence on Sardinia's biological history not to be neglected could be attributed to the demographic events, which triggered off phenomena of genetic drift and to cultural factors.read more
Citations
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Human Y-chromosome variation in the western Mediterranean area: implications for the peopling of the region.
Rosaria Scozzari,Fulvio Cruciani,Alessandra Pangrazio,P Santolamazza,Giuseppe Vona,Pedro Moral,Veronica Latini,Laurent Varesi,Marc Memmi,Valentino Romano,Giacomo De Leo,Massimo Gennarelli,Jadwiga Jaruzelska,Richard Villems,Jüri Parik,Vincent Macaulay,Antonio Torroni,Antonio Torroni +17 more
TL;DR: This study demonstrates that the dissection of Y-chromosome variation into haplogroups with a more restricted geographic distribution can reveal important differences even between populations that live at short distances, and provides new clues to their past interactions.
Journal ArticleDOI
Genomic history of the Sardinian population
Charleston W. K. Chiang,Charleston W. K. Chiang,Joseph Marcus,Carlo Sidore,Arjun Biddanda,Hussein Al-Asadi,Magdalena Zoledziewska,Maristella Pitzalis,Fabio Busonero,Andrea Maschio,Giorgio Pistis,Maristella Steri,Andrea Angius,Kirk E. Lohmueller,Gonçalo R. Abecasis,David Schlessinger,Francesco Cucca,John Novembre +17 more
TL;DR: Analysis of 3,514 whole-genome-sequenced individuals from Sardinia indicates that within-island substructure and sex-biased processes have impacted the genetic history of Sardinia, providing new insight into the demography of ancestral Sardinians.
Journal ArticleDOI
Inferring Genealogical Processes from Patterns of Bronze-Age and Modern DNA variation in Sardinia
Silvia Ghirotto,Stefano Mona,Andrea Benazzo,Francesco Paparazzo,Francesco Paparazzo,David Caramelli,Guido Barbujani +6 more
TL;DR: It is shown that a direct genealogical continuity between Bronze-Age Sardinians and the current people of Ogliastra, but not Gallura, has a much higher probability than any alternative scenarios and that genetic diversity in Gallura evolved largely independently, owing in part to gene flow from the mainland.
Journal ArticleDOI
GBS-derived SNP catalogue unveiled wide genetic variability and geographical relationships of Italian olive cultivars.
Nunzio D’Agostino,Francesca Taranto,Salvatore Camposeo,Giacomo Mangini,Valentina Fanelli,Susanna Gadaleta,Monica Marilena Miazzi,Stefano Pavan,Valentina di Rienzo,Wilma Sabetta,Luca Lombardo,Samanta Zelasco,Enzo Perri,Concetta Lotti,Elena Ciani,Cinzia Montemurro +15 more
TL;DR: Genotype-by-sequencing on a panel of 94 Italian olive cultivars allowed us to formulate hypotheses about geographical relationships of Italian Olive cultivars and to confirm known and uncover novel cases of synonymy.
Journal ArticleDOI
Sardinians genetic background explained by runs of homozygosity and genomic regions under positive selection.
Cornelia Di Gaetano,Giovanni Fiorito,Maria Francesca Ortu,Fabio Rosa,Simonetta Guarrera,Barbara Pardini,Daniele Cusi,Francesca Frau,Cristina Barlassina,Chiara Troffa,Giuseppe Argiolas,Roberta Zaninello,Giovanni Fresu,Nicola Glorioso,Alberto Piazza,Giuseppe Matullo +15 more
TL;DR: The present study confirmed the high genetic homogeneity of Sardinia that may be explained by the shared ancestry combined with the action of evolutionary forces.
References
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Journal ArticleDOI
Genetic analysis of Sardinia: I. Data on 12 polymorphisms in 21 linguistic domains
Nazario Cappello,S. Rendine,R.M. Griffo,G. E. Mameli,Valeria Succa,Giuseppe Vona,Alberto Piazza +6 more
TL;DR: The microgeographic structure of Sardinia, well documented from a historical and linguistic point of view, and further supported by archaeological evidence, can be dissected at the genetic level: gene frequencies show heterogeneities which are statistically significant.
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Genetic data on Alghero population (Sardinia): Contrast between biological and cultural evidence
TL;DR: The genetic results do not support any interpretation of the linguistic affinities between Alghero and Catalonia at present as indicative of biological kinship, and analysis for heterogeneity of gene frequency distributions indicates that the genetic information obtained on Alg hero is adequate to discriminate Sardinians from other neighbouring populations.
Journal ArticleDOI
Red cell and serum protein polymorphisms in Sardinia
TL;DR: Four Sardinian population samples were studied with regard to the erythrocyte enzyme systems ACP, ESD, PGM1, ADA, AK, 6PGD and Dia, and to the serum protein systems GC and C3.
Journal ArticleDOI
Blood groups of the Sardinian population (Italy).
TL;DR: The genetic polymorphism of eight red cell blood group systems was examined in a population sample from Sardinia (Italy) and confirmed the genetic peculiarity of the Sardinian population.