The promising expedition of the delivery systems for monoclonal antibodies

TLDR: An overview of the mAbs origin, types and new utilizations for diagnosis and treatment of many challenging diseases along with the diversity of the employed mAbs delivery systems are covered in this chapter.

Abstract: Monoclonal antibodies (mAbs) are advantaged with high homogeneity and very specific antigen-binding capability. In the last 50 years, mAbs are widely utilized for their splendid therapeutic efficacy with markedly low side effects. Regarding cancer immunotherapy, checkpoints antibodies that delivered to their sites of action were proved to enhance vastly the body’s immune system to identify and solely exterminate cancer cells. Despite the challenges and complications faced due to the protein nature of these mAbs along with the lack of targeting ability, many successful formulations and delivery systems were raised and evidenced. In this chapter, an overview of the mAbs origin, types and new utilizations for diagnosis and treatment of many challenging diseases along with the diversity of the employed mAbs delivery systems are covered. Furthermore, the know-how of conquering the challenges provoked using these systems is critically illustrated and the clinical transition of several mAbs formulations from bench to bed is exampled by many of already approved formulations. Finally, many prospective systems like microfluidics and local delivery techniques of mAbs are also emphasized in this chapter.