The REDCap consortium: Building an international community of software platform partners.
Paul A. Harris,Paul A. Harris,Robert Taylor,Brenda L. Minor,Veida Elliott,Michelle Fernandez,Lindsay O'Neal,Laura McLeod,Giovanni Delacqua,Francesco Delacqua,Jacqueline Kirby,Stephany N. Duda +11 more
TLDR
The Research Electronic Data Capture (REDCap) data management platform was developed in 2004 to address an institutional need at Vanderbilt University, then shared with a limited number of adopting sites beginning in 2006, and a broader consortium sharing and support model was created.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2019-05-09 and is currently open access. It has received 8712 citations till now. The article focuses on the topics: Electronic data capture & Health informatics.read more
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Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington.
Temet M. McMichael,Dustin W Currie,Shauna Clark,Sargis Pogosjans,Meagan Kay,Noah G. Schwartz,James S. Lewis,Atar Baer,Vance Kawakami,Margaret D. Lukoff,Jessica Ferro,Claire Brostrom-Smith,Thomas D. Rea,Michael R. Sayre,Francis X. Riedo,Denny Russell,Brian Hiatt,Patricia Montgomery,Agam K Rao,Eric J. Chow,Farrell A Tobolowsky,Michael J. Hughes,Ana C Bardossy,Lisa P. Oakley,Jesica R. Jacobs,Nimalie D. Stone,Sujan C. Reddy,John A. Jernigan,John A. Jernigan,Margaret A. Honein,Thomas A. Clark,Jeffrey S. Duchin +31 more
TL;DR: In this paper, the authors proposed that long-term care facilities are high-risk settings for severe outcomes from outbreaks of Covid-19, owing to both the advanced age and frequent chronic underlying health conditions.
Journal ArticleDOI
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
David R. Boulware,Matthew F Pullen,Ananta S. Bangdiwala,Katelyn A Pastick,Sarah M Lofgren,Elizabeth C Okafor,Caleb P Skipper,Alanna A Nascene,Melanie R. Nicol,Mahsa Abassi,Nicole W. Engen,Matthew P. Cheng,Derek LaBar,Sylvain A. Lother,Lauren J. MacKenzie,Glen Drobot,Nicole Marten,Ryan Zarychanski,Lauren E. Kelly,Ilan S. Schwartz,Emily G. McDonald,Radha Rajasingham,Todd C. Lee,Kathy H. Hullsiek +23 more
TL;DR: After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid -19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure.
Journal ArticleDOI
Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.
Bruno Martins Tomazini,Israel Silva Maia,Alexandre Biasi Cavalcanti,Otavio Berwanger,Regis Goulart Rosa,Viviane C Veiga,Alvaro Avezum,Renato D. Lopes,Flavia Regina Bueno,Maria Vitoria Aparecida Oliveira Silva,Franca Pellison Baldassare,Eduardo L. V. Costa,Ricardo Antonio Bonifácio Moura,Michele Ouriques Honorato,André Nathan Costa,Lucas P. Damiani,Thiago Lisboa,Leticia Kawano-Dourado,Fernando G. Zampieri,Guilherme B Olivato,Cassia Righy,Cristina Prata Amendola,Roberta Muriel Longo Roepke,Daniela H M Freitas,Daniel Neves Forte,Flávio Geraldo Resende Freitas,Caio C. Fernandes,Livia Maria Garcia Melro,Gedealvares F S Junior,Douglas Costa Morais,Stevin Zung,Flávia Ribeiro Machado,Luciano Cesar Pontes Azevedo,Coalition Covid Brazil Iii Investigators +33 more
TL;DR: Among patients with COVID-19 and moderate or severe ARDS, use of intravenous dexamethasone plus standard care compared with standard care alone resulted in a statistically significant increase in the number of ventilator-free days over 28 days.
Journal ArticleDOI
Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.
Alexandre Biasi Cavalcanti,Fernando G. Zampieri,Regis Goulart Rosa,Luciano Cesar Pontes Azevedo,Viviane C Veiga,Alvaro Avezum,Lucas P. Damiani,Aline Marcadenti,Leticia Kawano-Dourado,Thiago Lisboa,Debora L. M. Junqueira,Pedro Gabriel Melo de Barros e Silva,Lucas Tramujas,Erlon Oliveira de Abreu-Silva,Lígia Nasi Laranjeira,Aline T. Soares,Leandro S. Echenique,Adriano José Pereira,Flávio Geraldo Resende Freitas,Otavio Gebara,Vicente C.S. Dantas,Remo H.M. Furtado,Eveline P. Milan,Nicole A. Golin,Fábio F. Cardoso,Israel Silva Maia,Conrado R. Hoffmann Filho,Adrian P.M. Kormann,Roberto Bleuel Amazonas,Monalisa Fernanda Bocchi de Oliveira,Ary Serpa-Neto,Maicon Falavigna,Renato D. Lopes,Flávia Ribeiro Machado,Otavio Berwanger +34 more
TL;DR: Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care.
Journal ArticleDOI
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
Matthew C. Woodruff,Richard P. Ramonell,Doan C. Nguyen,Kevin S. Cashman,Ankur Singh Saini,Natalie S. Haddad,Ariel Ley,Shuya Kyu,J. Christina Howell,Tugba Ozturk,Saeyun Lee,Naveenchandra Suryadevara,James Brett Case,Regina Bugrovsky,Weirong Chen,Jacob Estrada,Andrea Morrison-Porter,Andrew Derrico,Fabliha Anam,Monika Sharma,Henry M. Wu,Sang N. Le,Scott A. Jenks,Christopher M. Tipton,Bashar S. Staitieh,John L. Daiss,Eliver Ghosn,Michael S. Diamond,Robert H. Carnahan,James E. Crowe,William T. Hu,F. Eun-Hyung Lee,Ignacio Sanz +32 more
TL;DR: Overall, these findings strongly suggest a pathogenic role for immune activation in subsets of patients with COVID-19, and provide further evidence that targeted immunomodulatory therapy may be beneficial in specific patient subpopulations and can be informed by careful immune profiling.
References
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Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support
Paul A. Harris,Robert W. Taylor,Robert J. Thielke,Jonathon Payne,Nathaniel Gonzalez,José G. Conde +5 more
TL;DR: Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data Capture tools to support clinical and translational research.
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Central challenges facing the national clinical research enterprise.
Nancy S. Sung,William F. Crowley,Myron Genel,Patricia Salber,Lewis G. Sandy,Louis M. Sherwood,Stephen B. Johnson,Veronica Catanese,Hugh H. Tilson,Kenneth A. Getz,Elaine Larson,David A. Scheinberg,E. Albert Reece,Harold C. Slavkin,Adrian S. Dobs,Jack Grebb,Rick A. Martinez,Allan Korn,David L. Rimoin +18 more
TL;DR: The goal of this article is to articulate the 4 central challenges facing clinical research at present--public participation, information systems, workforce training, and funding; to make recommendations about how they might be addressed by particular stakeholders; and to invite a broader, participatory dialogue with a view to improving the overall performance of the US clinical research enterprise.
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BioPortal: enhanced functionality via new Web services from the National Center for Biomedical Ontology to access and use ontologies in software applications
Patricia L. Whetzel,Natalya F. Noy,Nigam H. Shah,Paul R. Alexander,Csongor Nyulas,Tania Tudorache,Mark A. Musen +6 more
TL;DR: The National Center for Biomedical Ontology (NCBO) has developed BioPortal, a web portal that provides access to a library of biomedical ontologies and terminologies via the NCBO Web services.
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Launching PCORnet, a national patient-centered clinical research network
Rachael L. Fleurence,Lesley H. Curtis,Robert M. Califf,Richard Platt,Joe V. Selby,Jeffrey S. Brown +5 more
TL;DR: The Patient-Centered Outcomes Research Institute has launched PCORnet, a major initiative to support an effective, sustainable national research infrastructure that will advance the use of electronic health data in comparative effectiveness research (CER) and other types of research.
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Global software development and collaboration: barriers and solutions
TL;DR: It is found that the key barriers to collaboration are geographic, temporal, cultural, and linguistic distance; the primary solutions to overcoming these barriers include site visits, synchronous communication technology, and knowledge sharing infrastructure to capture implicit knowledge and make it explicit.