Journal ArticleDOI
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Jérémie Sellam,Francis Berenbaum +1 more
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TLDR
As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progression.Abstract:
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain The gold-standard method for detecting synovitis is histological analysis of samples obtained by biopsy, but the noninvasive imaging techniques MRI and ultrasonography might also perform well The inflammation of the synovial membrane that occurs in both the early and late phases of OA is associated with alterations in the adjacent cartilage that are similar to those seen in rheumatoid arthritis Catabolic and proinflammatory mediators such as cytokines, nitric oxide, prostaglandin E(2) and neuropeptides are produced by the inflamed synovium and alter the balance of cartilage matrix degradation and repair, leading to excess production of the proteolytic enzymes responsible for cartilage breakdown Cartilage alteration in turn amplifies synovial inflammation, creating a vicious circle As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progressionread more
Citations
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Journal ArticleDOI
Osteoarthritis: an update with relevance for clinical practice
TL;DR: In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease, and treatment targeted more specifically at these phenotypes might lead to improved outcomes.
Journal ArticleDOI
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis
TL;DR: Low-grade inflammation induced by the metabolic syndrome, innate immunity and inflammaging are some of the more recent arguments in favor of the inflammatory theory of OA and highlighted in this review.
Journal ArticleDOI
Inflammation in osteoarthritis
Mary B. Goldring,Miguel Otero +1 more
TL;DR: This review focuses on the novel stress-induced and proinflammatory mechanisms underlying the pathogenesis of osteoarthritis, with particular attention to the role of synovitis and the contributions of other joint tissues to cellular events that lead to the onset and progression of the disease and irreversible cartilage damage.
Journal ArticleDOI
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Ok-Hee Jeon,Chaekyu Kim,Chaekyu Kim,Remi-Martin Laberge,Marco Demaria,Marco Demaria,Sona Rathod,Alain Philippe Vasserot,Jae Wook Chung,Do Hun Kim,Yan Poon,Nathaniel David,Darren J. Baker,Jan M. van Deursen,Judith Campisi,Judith Campisi,Jennifer H. Elisseeff +16 more
TL;DR: It is found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selective elimination of these cells attenuated the development of post-traumatic OA, reduced pain and increased cartilage development, which support the use of SnCs as a therapeutic target for treating degenerative joint disease.
Journal ArticleDOI
The role of synovitis in osteoarthritis pathogenesis
TL;DR: Most studies have concluded that the presence of synovitis in OA is associated with more severe pain and joint dysfunction, and may be predictive of faster rates of cartilage loss in certain patient populations.
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Journal ArticleDOI
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