The Role of Vimentin Intermediate Filaments in Cortical and Cytoplasmic Mechanics
Ming Guo,Allen J. Ehrlicher,Allen J. Ehrlicher,Saleemulla Mahammad,Hilary Fabich,Mikkel H. Jensen,Mikkel H. Jensen,Jeffrey R. Moore,Jeffrey J. Fredberg,Robert D. Goldman,David A. Weitz +10 more
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Studying mouse embryonic fibroblasts derived from wild-type or vimentin(-/-) mice shows that VIFs both increase the mechanical integrity of cells and localize intracellular components.About:
This article is published in Biophysical Journal.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Cytoskeleton & Intermediate filament.read more
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Models to study intermediate filament dynamics and functions
TL;DR: This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Central American region.
Book ChapterDOI
Mechanical Sensing of Living Systems — From Statics to Dynamics
TL;DR: This chapter reviews methods and techniques that have been implemented to decipher the cascade of temporal events which enable a cell to sense a mechanical stimulus and to elaborate a response to adapt or to counteract this perturbation.
Journal ArticleDOI
Circular RNAs as the pivotal regulators of epithelial-mesenchymal transition in gastrointestinal tumor cells.
Reihaneh Alsadat Mahmoudian,Iman Akhlaghipour,Malihe Lotfi,Soodabeh Shahidsales,Meysam Moghbeli +4 more
TL;DR: In this article , the role of circRNAs in EMT process during GI tumor invasion is discussed, which can be an effective step in introducing a circRNA/EMT based diagnostic panel marker for the early tumor detection among GI cancer patients.
Posted ContentDOI
Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies
C. Mukherjee,C. Mukherjee,Avijit Kundu,Raunak Dey,Ayan Banerjee,Kaushik Sengupta,Kaushik Sengupta +6 more
TL;DR: In this paper, the application of active microrheology employing oscillating optical tweezers to investigate any alterations in the visco-elastic parameters of the mutant protein meshwork in vitro, which might translate into possible changes in nuclear plasticity.
References
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Cell mechanics and the cytoskeleton
TL;DR: An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate.
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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
TL;DR: The molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities are explored.
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Scaling the microrheology of living cells.
Ben Fabry,Geoffrey N. Maksym,James P. Butler,Michael Glogauer,Daniel Navajas,Jeffrey J. Fredberg +5 more
TL;DR: A scaling law is reported that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix.
Journal ArticleDOI
Nonequilibrium mechanics of active cytoskeletal networks.
Daisuke Mizuno,Catherine Tardin,Christoph F. Schmidt,Christoph F. Schmidt,Fred C. MacKintosh +4 more
TL;DR: A quantitative theoretical model is presented connecting the large-scale properties of this active gel to molecular force generation and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate–dependent manner.