The Role of Vimentin Intermediate Filaments in Cortical and Cytoplasmic Mechanics
Ming Guo,Allen J. Ehrlicher,Allen J. Ehrlicher,Saleemulla Mahammad,Hilary Fabich,Mikkel H. Jensen,Mikkel H. Jensen,Jeffrey R. Moore,Jeffrey J. Fredberg,Robert D. Goldman,David A. Weitz +10 more
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TLDR
Studying mouse embryonic fibroblasts derived from wild-type or vimentin(-/-) mice shows that VIFs both increase the mechanical integrity of cells and localize intracellular components.About:
This article is published in Biophysical Journal.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Cytoskeleton & Intermediate filament.read more
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Nuclear Plasticity Increases Susceptibility to Damage During Confined Migration
Abhishek Mukherjee,Abhishek Mukherjee,Abhishek Mukherjee,Amlan Barai,Ramesh Singh,Wenyi Yan,Shamik Sen +6 more
TL;DR: Using a quasi-static plane strain finite element model, evolution of nuclear shape and stresses during confined migration of a cell through a deformable matrix is mapped and suggests plastic deformations of the nucleus during transit through stiff tissues may lead to bending-induced nuclear membrane dis-ruption and subsequent DNA damage.
Posted ContentDOI
Loss of vimentin intermediate filaments decreases peri-nuclear stiffness and enhances cell motility through confined spaces
Alison E. Patteson,Alison E. Patteson,Katarzyna Pogoda,Katarzyna Pogoda,Fitzroy J. Byfield,Elisabeth E. Charrier,Peter A. Galie,Peter A. Galie,Piotr Deptuła,Robert Bucki,Paul A. Janmey +10 more
TL;DR: In this paper, the effects of vimentin on cell motility and stiffness were investigated using mouse embryo fibroblasts derived from wild-type and Vimentin-null mice.
Book ChapterDOI
Mechanobiology, tissue development, and tissue engineering
David Li,Yu-li Wang +1 more
TL;DR: Mechanobiology is crucial to the understanding of many clinically relevant biological phenomena, such as morphogenesis, tissue regeneration, and cancer metastasis, and to the development of medical applications such as implants, wound healing, and tissue engineering.
Journal ArticleDOI
The Mechanical Contribution of Vimentin to Cellular Stress Generation.
Inge A. E. W. van Loosdregt,Giulia Weissenberger,Marc P.F.H.L. van Maris,Cees W. J. Oomens,S Sandra Loerakker,Oscar M. J. A. Stassen,Carlijn V. C. Bouten +6 more
TL;DR: The data suggest that vimentin resists the stress fiber contractility, as hypothesized, thus indicating the importance of vimentsin in regulating cellular stress generation by adherent cells.
Journal ArticleDOI
All-in-one rheometry and nonlinear rheology of multicellular aggregates.
Gaetan Mary,François Mazuel,Vincent Nier,Florian Fage,Irène Nagle,L. Devaud,Jean-Claude Bacri,Sophie Asnacios,Atef Asnacios,C. Gay,Philippe Marcq,Claire Wilhelm,Myriam Reffay +12 more
TL;DR: It is found that multicellular aggregates exhibit a power-law response with nonlinearities leading to tissue stiffening at high stress.
References
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Cell mechanics and the cytoskeleton
TL;DR: An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate.
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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
TL;DR: The molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities are explored.
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Ben Fabry,Geoffrey N. Maksym,James P. Butler,Michael Glogauer,Daniel Navajas,Jeffrey J. Fredberg +5 more
TL;DR: A scaling law is reported that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix.
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Nonequilibrium mechanics of active cytoskeletal networks.
Daisuke Mizuno,Catherine Tardin,Christoph F. Schmidt,Christoph F. Schmidt,Fred C. MacKintosh +4 more
TL;DR: A quantitative theoretical model is presented connecting the large-scale properties of this active gel to molecular force generation and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate–dependent manner.