The Role of Vimentin Intermediate Filaments in Cortical and Cytoplasmic Mechanics
Ming Guo,Allen J. Ehrlicher,Allen J. Ehrlicher,Saleemulla Mahammad,Hilary Fabich,Mikkel H. Jensen,Mikkel H. Jensen,Jeffrey R. Moore,Jeffrey J. Fredberg,Robert D. Goldman,David A. Weitz +10 more
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TLDR
Studying mouse embryonic fibroblasts derived from wild-type or vimentin(-/-) mice shows that VIFs both increase the mechanical integrity of cells and localize intracellular components.About:
This article is published in Biophysical Journal.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Cytoskeleton & Intermediate filament.read more
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The soft mechanical signature of glial scars in the central nervous system
Isabell P. Weber,Graham K. Sheridan,David E. Koser,Sara Soleman,Barbara Haenzi,Elizabeth J. Bradbury,James W. Fawcett,Kristian Franze,Emadaldin Moeendarbary +8 more
TL;DR: Describing spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using atomic force microscopy may help to understand why mammalian neurons do not regenerate after injury.
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Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy
Takeshi Shimi,Mark Kittisopikul,Joseph R. Tran,Anne E. Goldman,Stephen A. Adam,Yixian Zheng,Khuloud Jaqaman,Robert D. Goldman +7 more
TL;DR: Superresolution microscopy and computational image analysis demonstrate that the four nuclear lamin isoforms of mammalian cells are each organized into distinct meshwork structures sharing similar physical characteristics.
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The Cytoskeleton-A Complex Interacting Meshwork.
Tim Hohmann,Faramarz Dehghani +1 more
TL;DR: The findings about cytoskeletal filament types, including substructures formed by them, such as lamellipodia, stress fibers, and interactions between intermediate filaments, microtubules and actin are summarized.
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Vimentin Diversity in Health and Disease
Frida Danielsson,McKenzie Kirsten Peterson,Helena Caldeira Araújo,Franziska Lautenschläger,Annica K. B. Gad,Annica K. B. Gad +5 more
TL;DR: The present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentsin knockout animals.
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High-Throughput Assessment of Cellular Mechanical Properties
TL;DR: The current understanding of how the mechanical characteristics of cells relate to underlying molecular and architectural changes is reviewed, as well as new directions not only in mechanically assessing cells but also in perturbing them to passively engineer cell state.
References
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Cell mechanics and the cytoskeleton
TL;DR: An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate.
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Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
TL;DR: The molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities are explored.
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Scaling the microrheology of living cells.
Ben Fabry,Geoffrey N. Maksym,James P. Butler,Michael Glogauer,Daniel Navajas,Jeffrey J. Fredberg +5 more
TL;DR: A scaling law is reported that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix.
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Nonequilibrium mechanics of active cytoskeletal networks.
Daisuke Mizuno,Catherine Tardin,Christoph F. Schmidt,Christoph F. Schmidt,Fred C. MacKintosh +4 more
TL;DR: A quantitative theoretical model is presented connecting the large-scale properties of this active gel to molecular force generation and qualitatively changing the viscoelastic response of the network in an adenosine triphosphate–dependent manner.