Journal ArticleDOI
The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting.
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Six of the 7 mice that had surviving grafts containing histofluorescent dopamine neurons eventually showed a reversed motor side bias with more amphetamine-induced turning in a direction away from the transplant.About:
This article is published in Brain Research.The article was published on 1986-02-26. It has received 63 citations till now. The article focuses on the topics: Hydroxydopamine & Transplantation.read more
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Journal ArticleDOI
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.
H. Sauer,Wolfgang H. Oertel +1 more
TL;DR: It is concluded that injection of 6-hydroxydopamine into the terminal field of nigral dopaminergic neurons causes a progressive degeneration of these cells, starting between one and two weeks after lesion and continuing over eight to 16 weeks, yielding an animal model which mimics the degenerative processes in Parkinson's disease more closely than the animal models available so far.
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Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
TL;DR: It is demonstrated that substantial and stable unilateral 6-OHDA-induced lesions can be established in mice, and that these lesionsCan be functionally assessed using several different side-bias-based behavioral tests.
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Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease.
TL;DR: The results indicate that human fetal mesencephalic tissue may be an efficient source of dopamine neurons for functional intracerebral grafting in patients with Parkinson's disease.
Journal ArticleDOI
Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease
TL;DR: Inhibition of the JNK pathway offers a new treatment strategy for Parkinson's disease that blocks the death signaling pathway upstream of the execution of apoptosis in dopaminergic neurons, providing a therapeutic advantage over the direct inhibition of caspases.
Journal ArticleDOI
Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry
TL;DR: Grafting of human fetal DA neurons is expected to provide a means of restoring regulated synaptic DA release in patients with Parkinson's disease and provides tentative evidence for a time-link between the development of synaptic contacts and the appearance of functional graft effects.
References
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Journal ArticleDOI
Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
TL;DR: Fetal rat dopamine-containg neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed to suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.
Journal ArticleDOI
Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival.
TL;DR: Grafting experiments showed a good correlation between the in vitro cell viability counts and in vivo neuronal survival after grafting, indicating that the vital stain can be used as a simple and practical routine test to check and standardize cell suspensions to be used in intracerebral grafting experiments.
Journal ArticleDOI
In vitro maturation of mesencephalic dopaminergic neurons from mouse embryos is enhanced in presence of their striatal target cells
TL;DR: Long-term survival of mesencephalic and striatal cells from mouse embryos in dissociated primary cultures is described, and at least two-thirds of the catecholaminergic neurons are dopaminergic.
Journal ArticleDOI
Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency
Dorothy T. Krieger,M. J. Perlow,M. J. Gibson,T. F. Davies,Earl A. Zimmerman,M. Ferin,Harry M. Charlton +6 more
TL;DR: Fetal preoptic area (POA) from unaffected animals of the hpg strain was transplanted into the anterior third ventricle of adult hpg mice and Hypothalamic GnRH and pituitary and plasma gonadotropin concentrations were increased compared with levels in untreated animals.
Related Papers (5)
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.
Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants
Anders Björklund,Ulf Stenevi +1 more