The Rotterdam Study: 2018 update on objectives, design and main results.
M. Arfan Ikram,Guy Brusselle,Guy Brusselle,Sarwa Darwish Murad,Cornelia M. van Duijn,Oscar H. Franco,André Goedegebure,Caroline C W Klaver,Tamar Nijsten,Robin P. Peeters,Bruno H. Stricker,Henning Tiemeier,André G. Uitterlinden,Meike W. Vernooij,Albert Hofman,Albert Hofman +15 more
TLDR
The rationale of the study and its design is given, a summary of the major findings and an update of the objectives and methods are presented and the cohort is being expanded by persons aged 40 years and over.Abstract:
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy
). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.read more
Citations
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Objectives, design and main findings until 2020 from the Rotterdam Study.
M. Arfan Ikram,Guy Brusselle,Guy Brusselle,Mohsen Ghanbari,André Goedegebure,M. Kamran Ikram,Maryam Kavousi,Brenda C.T. Kieboom,Caroline C W Klaver,Robert J. de Knegt,Annemarie I. Luik,Tamar Nijsten,Robin P. Peeters,Frank J. A. van Rooij,Bruno H. Stricker,André G. Uitterlinden,Meike W. Vernooij,Trudy Voortman +17 more
TL;DR: An update on the rationale and design of the Rotterdam Study is provided and a summary of the major findings from the preceding 3 years is presented and developments for the coming period are outlined.
Journal ArticleDOI
FastSurfer - A fast and accurate deep learning based neuroimaging pipeline
Leonie Henschel,Sailesh Conjeti,Santiago Estrada,Kersten Diers,Bruce Fischl,Martin Reuter,Martin Reuter +6 more
TL;DR: This work proposes a fast and accurate deep learning based neuroimaging pipeline for the automated processing of structural human brain MRI scans, replicating FreeSurfer’s anatomical segmentation including surface reconstruction and cortical parcellation.
Journal ArticleDOI
The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study.
Sven J. van der Lee,Frank J. Wolters,M. Kamran Ikram,Albert Hofman,Albert Hofman,M. Arfan Ikram,Najaf Amin,Cornelia M. van Duijn,Cornelia M. van Duijn +8 more
TL;DR: Common variants with small individual effects jointly modify the risk and age at onset of Alzheimer's disease and dementia, particularly in APOE ε4 carriers, which highlights the potential of common variants in determining Alzheimer's Disease risk.
Journal ArticleDOI
Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study
Frank de Wolf,Frank de Wolf,Mohsen Ghanbari,Mohsen Ghanbari,Silvan Licher,Kevin McRae-McKee,L. Gras,Gerrit Jan Weverling,Paulien R. Wermeling,Sanaz Sedaghat,M. Kamran Ikram,Reem Waziry,Wouter Koudstaal,J.M. Klap,Stefan Kostense,Albert Hofman,Roy M. Anderson,Jaap Goudsmit,Jaap Goudsmit,M. Arfan Ikram,M. Arfan Ikram +20 more
TL;DR: It is shown that low amyloid-β42 and high NfL levels are associated, both independently and in combination, with an increased risk of dementia and Alzheimer’s disease.
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Hieab H.H. Adams,Derrek P. Hibar,Vincent Chouraki,Jason L. Stein,Paul A. Nyquist,Miguel E. Rentería,Stella Trompet,Alejandro Arias-Vásquez,Sudha Seshadri,Sylvane Desrivières,Ashley Beecham,Neda Jahanshad,Katharina Wittfeld,Tatiana Foroud +13 more
TL;DR: In this paper, the authors identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits, including PI3K-AKT signaling.
References
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Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction The Rotterdam Study
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