Journal ArticleDOI
Broken Limits to Life Expectancy
Jim Oeppen,James W. Vaupel +1 more
Reads0
Chats0
TLDR
The evidence presented in this paper suggests that the apparent leveling off of life expectancy in various countries is an artifact of laggards catching up and leaders falling behind, not a sign that life expectancy is approaching its limit.Abstract:
Is human life expectancy approaching its limit? Many--including individuals planning their retirement and officials responsible for health and social policy--believe it is, but the evidence presented in the
Policy Forum
suggests otherwise. For 160 years, best-performance life expectancy has steadily increased by a quarter of a year per year, an extraordinary constancy of human achievement. Mortality experts have repeatedly asserted that life expectancy is close to an ultimate ceiling; these experts have repeatedly been proven wrong. The apparent leveling off of life expectancy in various countries is an artifact of laggards catching up and leaders falling behind.read more
Citations
More filters
Journal ArticleDOI
A gradient of childhood self-control predicts health, wealth, and public safety
Terrie E. Moffitt,Louise Arseneault,Daniel W. Belsky,Nigel Dickson,Robert J. Hancox,HonaLee Harrington,Renate Houts,Richie Poulton,Brent W. Roberts,Stephen A. Ross,Malcolm R. Sears,W. Murray Thomson,Avshalom Caspi +12 more
TL;DR: Following a cohort of 1,000 children from birth to the age of 32 y, it is shown that childhood self-control predicts physical health, substance dependence, personal finances, and criminal offending outcomes, following a gradient of self- control.
Journal ArticleDOI
Ageing populations: the challenges ahead
TL;DR: Research suggests that ageing processes are modifiable and that people are living longer without severe disability, and this finding will be important for the chances to meet the challenges of ageing populations.
Journal ArticleDOI
A Potential Decline in Life Expectancy in the United States in the 21st Century
S. Jay Olshansky,Douglas J. Passaro,Ronald C. Hershow,Jennifer E. Layden,Bruce A. Carnes,Jacob A. Brody,Leonard Hayflick,Robert N. Butler,David B. Allison,David S. Ludwig +9 more
TL;DR: From an analysis of the effect of obesity on longevity, it is concluded that the steady rise in life expectancy during the past two centuries may soon come to an end.
Journal ArticleDOI
ADOLESCENT RESILIENCE: A Framework for Understanding Healthy Development in the Face of Risk
TL;DR: The authors discuss three models of resilience, the compensatory, protective, and challenge models, and describe how resilience differs from related concepts, and discuss implications that resilience research has for intervention and describe some resilience-based interventions.
Journal ArticleDOI
Aging with multimorbidity: a systematic review of the literature
Alessandra Marengoni,Sara Angleman,René J. F. Melis,René J. F. Melis,Francesca Mangialasche,Anita Karp,Annika Garmen,Bettina Meinow,Laura Fratiglioni +8 more
TL;DR: Methodological issues in evaluating multimorbidity are discussed as well as future research needs, especially concerning etiological factors, combinations and clustering of chronic diseases, and care models for persons affected by multiple disorders.
References
More filters
Journal ArticleDOI
Oxidants, oxidative stress and the biology of ageing.
Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Journal ArticleDOI
Pleiotropy, natural selection, and the evolution of senescence
TL;DR: August Weismann's theory is subject to a number of criticisms, the most forceful of which are: 1) The fallacy of identifying senescence with mechanical wear, 2) the extreme rarity, in natural populations, of individuals that would be old enough to die of the postulated death-mechanism, 3) the failure of several decades of gerontological research to uncover any deathmechanisms, and 4) the difficulties involved in visualizing how such a feature could be produced
Journal Article
Pleiotropy, Natural Selection, and the Evolution of Senescence
TL;DR: A new individual entering a population may be said to have a reproductive probability distribution as discussed by the authors, where the reproductive probability is zero from zygote to reproductive maturity, i.e., the individual will have no reproductive capability from birth to maturity.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
A C. elegans mutant that lives twice as long as wild type
TL;DR: Finding that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type raises the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation.