Book ChapterDOI
The serum transport of steroid hormones.
TLDR
This chapter discusses the serum transport of steroid hormones, where the steroid-receptor complex apparently moves into the nucleus where it modifies the chromatin transcriptional activity which results in altered levels of protein synthesis.Abstract:
Publisher Summary This chapter discusses the serum transport of steroid hormones Steroid hormones are extensively bound to plasma proteins including albumin, corticosteroid binding globulin (CBG), and sex hormone binding globulin (SHBG) Because of its high concentration, albumin binding is important in determining the magnitude of the nonprotein bound or free fraction of a steroid in plasma The generally accepted model of steroid hormone action suggests that free steroid (in equilibrium with circulating binding proteins) diffuses passively through target cell membranes and binds to a soluble intracellular receptor The steroid-receptor complex apparently moves into the nucleus where it modifies the chromatin transcriptional activity which results in, among other things, altered levels of protein synthesis CBG has been differentiated from the intracellular glucocorticoid and progesterone receptors by its inability to bind synthetic glucocorticoids and progestinsread more
Citations
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Journal ArticleDOI
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
TL;DR: Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
Journal ArticleDOI
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
Journal ArticleDOI
Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation
TL;DR: It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target.
Journal ArticleDOI
Brain corticosteroid receptor balance in health and disease.
TL;DR: The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.
Journal ArticleDOI
Androgen Receptor in Prostate Cancer
TL;DR: AR remains important in the development and progression of prostate cancer and the inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression.
References
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Journal ArticleDOI
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
Journal ArticleDOI
A method for producing specific antisera with small doses of immunogen.
TL;DR: The method has succeeded in producing specific antisera to the subunits of HCG and testosterone conjugates with one immunization of 20 to 100 μg of immunogen, and the potential of the method for producing specificantisers to glycoprotein and other hormones with limited amounts of purified material prompts this report.
Journal ArticleDOI
Transport of Steroid Hormones: Binding of 21 Endogenous Steroids to Both Testosterone-Binding Globulin and Corticosteroid-Binding Globulin in Human Plasma
TL;DR: A model of steroid transport in human plasma is described, finding that normal men, normal women during both the follicular and luteal phases of the ovarian cycle, and women during the third trimester of a normal pregnancy are candidates for steroid transport.
Journal ArticleDOI
Sex-hormone-binding globulin.
TL;DR: By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed, and the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.
Journal ArticleDOI
Binding of Diffusible Molecules by Macromolecules: Rapid Measurement by Rate of Dialysis
TL;DR: A rapid technique for the determination of the dissociation constant and the number of binding sites of an enzyme-substrate complex has been developed based on measuring the rate of dialysis of radioactive substrate from an enzyme -substrate equilibrium mixture.