Journal ArticleDOI
The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
Murray Coles,Tammo Diercks,Bernd Muehlenweg,Stefan Bartsch,Volker Zölzer,Harald Tschesche,Horst Kessler +6 more
TLDR
The structure provides a detailed model of the ligand-binding site and has led to the proposal of a site for pro-MMP-9 association, which has allowed us to investigate a mechanism by which a cell-surface receptor might distinguish between apo and holo-HNGAL through conformational changes at the open end of the barrel.About:
This article is published in Journal of Molecular Biology.The article was published on 1999-05-28. It has received 99 citations till now. The article focuses on the topics: Protein structure & Protein secondary structure.read more
Citations
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Journal ArticleDOI
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
David H. Goetz,Margaret A. Holmes,Niels Borregaard,Martin E. Bluhm,Kenneth N. Raymond,Roland K. Strong +5 more
TL;DR: It is proposed that NGAL participates in the antibacterial iron depletion strategy of the innate immune system by tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent in iron-limiting conditions.
Journal ArticleDOI
The lipocalin protein family: structural and sequence overview.
TL;DR: The lipocalins are part of a larger protein superfamily: the calycins, which includes the fatty acid binding proteins, avidins, a group of metalloproteinase inhibitors, and triabin, and are characterised by a similar structure and by the conservation of a remarkable structural signature.
Journal ArticleDOI
Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery.
Gebhard Wagener,Michael Jan,Mihwa Kim,Kiyoshi Mori,Jonathan Barasch,Robert N. Sladen,H. Thomas Lee +6 more
TL;DR: Urinary NGAL may be a useful early biomarker of ARD after cardiac surgery and facilitate the early detection of acute renal injury and potentially prevent progression to acute renal failure.
Journal ArticleDOI
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
TL;DR: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular reactive oxygen species (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive as discussed by the authors.
Repository
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
TL;DR: It is argued that the role of poorly liganded iron has been rather underappreciated in the past, and that in combination with peroxide and superoxide its activity underpins the behaviour of a great many physiological processes that degrade over time.
References
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Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.
TL;DR: It is demonstrated in this work that the surface tension, water‐organic solvent, transfer‐free energies and the thermodynamics of melting of linear alkanes provide fundamental insights into the nonpolar driving forces for protein folding and protein binding reactions.
Journal ArticleDOI
Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity
Giovanni Lipari,Attila Szabo +1 more
TL;DR: In this article, a model-free approach to the interpretation of nuclear magnetic resonance relaxation experiments on macromolecules in solution is presented, which uses the above spectral density to least-squares fit relaxation data by treating S/sup 2 and T/sub e/ as adjustable parameters.
Book
X-PLOR Version 3.1: A System for X-ray Crystallography and NMR
TL;DR: This manual to X-PLOR Version 3.1 presents the theoretical background, syntax and function of the programme and also provides a comprehensive list of references and sample input files with comments.