The surveillance of spike protein for patients with COVID-19 detected in Hong Kong in 2020.
Gannon C.K. Mak,Angela W.L. Lau,Andy M Y Chan,Edman T.K. Lam,Rickjason C.W. Chan,Dominic N.C. Tsang +5 more
TLDR
In this paper, the authors summarize the S protein mutations detected among coronavirus disease 2019 (COVID-19) patients in Hong Kong in 2020, and the full encoding region of the S proteins was sequenced.Abstract:
In 2020, numerous fast-spreading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported. These variants had unusually high genetic changes in the spike (S) protein. In an attempt to understand the genetic background of SARS-CoV-2 viruses in Hong Kong, especially before vaccination, the purpose of this study is to summarize the S protein mutations detected among coronavirus disease 2019 (COVID-19) patients in Hong Kong in 2020. COVID-19 cases were selected every month in 2020. One virus from each case was analyzed. The full encoding region of the S proteins was sequenced. From January 2020 to December 2020, a total of 340 COVID-19 viruses were sequenced. The amino acids of the S protein for 44 (12.9%) were identical to the reference sequence, WIV04 (GenBank accession MN996528). For the remaining 296 sequences (87.1%), a total of 43 nonsynonymous substitution patterns were found. Of the nonsynonymous substitutions found, some of them were only detected at specific time intervals and then they disappeared. The ongoing genetic surveillance system is important. It would facilitate early detection of mutations that can increase infectivity as well as mutations that are selected for the virus to escape immunological restraint.read more
Citations
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The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia.
TL;DR: In this article, the authors conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant, and found that populations infected predominantly with the G-614 virus had a much higher prevalence of anosmia (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D-6G mutation.
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The D614G virus mutation enhances anosmia in COVID-19 patients: Evidence from a systematic review and meta-analysis of studies from South Asia
TL;DR: In this article, the authors conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant and found that populations infected predominantly with the G6G mutation had a much higher prevalence of chemosensory dysfunction (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D6g mutation.
Journal ArticleDOI
Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
Alan K.L. Tsang,Gannon C.K. Mak,Peter K.C. Cheng,Peter C.W. Yip,Ken H.L. Ng,Edman T.K. Lam,Rickjason C.W. Chan,Dominic N.C. Tsang +7 more
TL;DR: In this article, SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays and preliminary positive cases were further tested by whole genome sequencing.
Journal ArticleDOI
Unusual high number of spike protein mutations for the SARS-CoV-2 strains detected in Hong Kong
Alan K.L. Tsang,Peter K.C. Cheng,Gannon C. K. Mak,P K L Leung,P. Yip,Edman Tk Lam,K. H. Ng,Rickjason C.W. Chan +7 more
References
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Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
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Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa
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TL;DR: In this paper, the authors describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y).
Journal ArticleDOI
The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2.
Vincent C.C. Cheng,Shuk Ching Wong,Vivien W M Chuang,Simon Y.C. So,Jonathan H. K. Chen,Siddharth Sridhar,Kelvin K. W. To,Jasper Fuk-Woo Chan,Ivan Hung,Pak-Leung Ho,Kwok-Yung Yuen +10 more
TL;DR: Community-wide mask wearing may contribute to the control of CO VID-19 by reducing virus shedding in saliva and respiratory droplets from individuals with subclinical or mild COVID-19.
Journal ArticleDOI
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant.
Xianding Deng,Miguel Garcia-Knight,Mir M. Khalid,Venice Servellita,Candace Wang,Mary Kate Morris,Alicia Sotomayor-Gonzalez,Dustin R. Glasner,Kevin Reyes,Amelia S. Gliwa,Nikitha P. Reddy,Claudia Sanchez San Martin,Scot Federman,Jing Cheng,Joanna Balcerek,Jordan E. Taylor,Jessica Streithorst,Steve Miller,Bharath Sreekumar,Pei-Yi Chen,Ursula Schulze-Gahmen,Taha Y. Taha,Jennifer M. Hayashi,Camille R. Simoneau,G. Renuka Kumar,Sarah McMahon,Peter V. Lidsky,Yinghong Xiao,Peera Hemarajata,Nicole M. Green,Alex Espinosa,Chantha Kath,Monica Haw,John Bell,Jill K. Hacker,Carl L. Hanson,Debra A. Wadford,Carlos Anaya,Donna Ferguson,Phillip A. Frankino,Haridha Shivram,Liana F. Lareau,Stacia K. Wyman,Melanie Ott,Melanie Ott,Raul Andino,Charles Y. Chiu +46 more
TL;DR: In this article, the authors identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the western United States.
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