The value of advanced MRI techniques in the assessment of cervical cancer: a review
Evelyn Dappa,Tania Elger,Annette Hasenburg,Christoph Düber,Marco Johannes Battista,Andreas M. Hötker +5 more
TLDR
New advanced MRI techniques can improve TNM staging and show promise for tumour classification and for assessing the risk of tumour recurrence and may be helpful for developing optimised and personalised therapy for patients with cervical cancer.Abstract:
To assess the value of new magnetic resonance imaging (MRI) techniques in cervical cancer. We searched PubMed and MEDLINE and reviewed articles published from 1990 to 2016 to identify studies that used MRI techniques, such as diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and dynamic contrast enhancement (DCE) MRI, to assess parametric invasion, to detect lymph node metastases, tumour subtype and grading, and to detect and predict tumour recurrence. Seventy-nine studies were included. The additional use of DWI improved the accuracy and sensitivity of the evaluation of parametrial extension. Most studies reported improved detection of nodal metastases. Functional MRI techniques have the potential to assess tumour subtypes and tumour grade differentiation, and they showed additional value in detecting and predicting treatment response. Limitations included a lack of technical standardisation, which limits reproducibility. New advanced MRI techniques allow improved analysis of tumour biology and the tumour microenvironment. They can improve TNM staging and show promise for tumour classification and for assessing the risk of tumour recurrence. They may be helpful for developing optimised and personalised therapy for patients with cervical cancer. • Conventional MRI plays a key role in the evaluation of cervical cancer.
• DWI improves tumour delineation and detection of nodal metastases in cervical cancer.
• Advanced MRI techniques show promise regarding histological grading and subtype differentiation.
• Tumour ADC is a potential biomarker for response to treatment.read more
Citations
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Journal ArticleDOI
Role of MRI in staging and follow-up of endometrial and cervical cancer: pitfalls and mimickers
Maria Milagros Otero-García,Alicia Mesa-Álvarez,Olivera Nikolic,Patricia Blanco-Lobato,Marijana Basta-Nikolic,Rafael Menéndez de Llano-Ortega,Laura Paredes-Velázquez,Nikola Nikolic,Magdalena Szewczyk-Bieda +8 more
TL;DR: Functional MRI with DWI and DCE sequences can help establish a correct diagnosis, although it is sometimes necessary to perform biopsy and histopathological analysis.
Journal ArticleDOI
The management of locally advanced cervical cancer.
TL;DR: Advanced imaging modalities are increasingly being utilized to tailor treatments and cisplatin-based concurrent chemoradiation is the standard of care, but more aggressive systemic therapies and use of newer agents still remains investigational.
Journal ArticleDOI
Imaging diagnosis and staging of pancreatic ductal adenocarcinoma: a comprehensive review.
TL;DR: The challenges related to the imaging of PDAC are discussed, including radiological and clinical subtleties of the tumor, evolving imaging criteria for tumor resectability, preoperative diagnosis of accompanying celiac artery stenosis, and post-neoadjuvant therapy imaging.
Journal ArticleDOI
British Gynaecological Cancer Society (BGCS) cervical cancer guidelines: Recommendations for practice.
Nicholas S. Reed,Janos Balega,Tara Barwick,Lynn Buckley,Kevin Burton,Gemma Eminowicz,Jenny Forrest,Raji Ganesan,Rosie L. Harrand,Cathrine M Holland,Tamara Howe,Thomas Ind,Rema Iyer,Sonali Kaushik,Robert Music,A. Sadozye,Smruta Shanbhag,Nadeem Siddiqui,Sheeba Syed,Natalie Percival,Natasha Lauren Whitham,Andy Nordin,Christina Fotopoulou +22 more
TL;DR: This guideline aims to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK and Malignant melanoma may present via similar routes and will be discussed.
Journal ArticleDOI
The MR radiomic signature can predict preoperative lymph node metastasis in patients with esophageal cancer.
Jinrong Qu,Jinrong Qu,Chen Shen,Chen Shen,Jianjun Qin,Zhaoqi Wang,Zhenyu Liu,Jia Guo,Hongkai Zhang,Pengrui Gao,Tianxia Bei,Yingshu Wang,Hui Liu,Ihab R. Kamel,Jie Tian,Jie Tian,Hailiang Li +16 more
TL;DR: MRI radiomic features showed the ability to predict LN metastasis in EC patients and showed good discrimination between metastatic and non-metastatic lymph nodes, according to the area under receiver-operating characteristic curve.
References
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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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TL;DR: Clinical results showed significant promise of the IVIM method for tissue characterization by perfusion patterns and for functional studies in the evaluation of the microcirculation in physiologic and pathologic conditions, as, for instance, in brain ischemia.
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Corrigendum to Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium
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TL;DR: An introduction into the basics of DWI and Diffusion Tensor imaging is provided and the potential of various MR sequences in concert with diffusion preparation are discussed with respect to acquisition speed, spatial resolution, and sensitivity to bulk physiologic motion.
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