Theranostic liposomes for cancer diagnosis and treatment: current development and pre-clinical success.
Madaswamy S Muthu,Si-Shen Feng +1 more
TLDR
In the present editorial, the advantages of vitamin E TPGS-coated liposomes over the currently available PEG-coating liposome will be described and their great potentials for nanotheranostics for cancer imaging and therapy will be covered.Abstract:
Liposomes are one of the effective drug delivery systems that are developed based on the nanotechnology concept. Liposomal formulation is the first nanomedicine approved by the US FDA for clinical application. Recently, the marketed liposomes and stealth liposomes have made impact for cancer therapy. In addition, a few receptor-targeted liposome products have been in different phases of clinical trials, which are yet to be marketed. In the present editorial, the advantages of vitamin E TPGS-coated liposomes over the currently available PEG-coated liposomes will be described and their great potentials for nanotheranostics for cancer imaging and therapy will be covered.read more
Citations
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New Developments in Liposomal Drug Delivery.
TL;DR: Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin study the role of phosphorous in the biosynthesis of Membrane Proteins and found that phosphorous binds to polypeptide A in a manner similar to that of polymethine.
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Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Sarwar Hossen,M. Khalid Hossain,Mohammad Khairul Basher,M.N.H. Mia,Moizur Rahman,M. Jalal Uddin +5 more
TL;DR: In this paper, the authors highlight the recent development of smart drug delivery systems for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles and carbon nanotubes.
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Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine
TL;DR: Recent advances of smart nanocarriers composed of organic and inorganic materials offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine are highlighted.
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Nanotheranostics ˗ Application and Further Development of Nanomedicine Strategies for Advanced Theranostics
TL;DR: This review summarizes the various nanocarriers developed so far in the literature for nanotheranostics, which include polymer conjugations, dendrimers, micelles, liposomes, metal and inorganic nanoparticles, carbon nanotubes, and nanoparticles of biodegradable polymers for sustained, controlled and targeted co-delivery of diagnostic and therapeutic agents for better theranostic effects with fewer side effects.
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Nanoparticles and nanofibers for topical drug delivery.
TL;DR: This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery and provides significant evidence that this area of research has - and will continue to have - a profound impact on both clinical outcomes and the development of new products.
References
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Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
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Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine
TL;DR: Two examples of liposomes-nanoparticle hybrids developed as theranostics are described: liposome-quantum dot hybrids loaded with a cytotoxic drug (doxorubicin) and artificially enveloped adenoviruses.
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Vitamin E TPGS as a molecular biomaterial for drug delivery
TL;DR: TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.
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Theranostic nanoplatforms for simultaneous cancer imaging and therapy: current approaches and future perspectives
TL;DR: Several exemplary nanoparticle platforms such as polymeric nanoparticles, gold nanomaterials, carbon nanotubes, magnetic nanoparticles and silica nanoparticles are elaborated on and future challenges of nanoparticle-based systems will be discussed.
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Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots.
TL;DR: The targeting multi-functional liposome showed greater efficacy than the non-targeting liposomes and thus great potential to improve the cancer imaging and therapy.