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Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels
Neeraj Gilhotra,Dinesh Dhingra +1 more
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The present study suggests an involvement of NO-cGMP and GABAergic pathways in the anxiolytic-like activity of thymoquinone in mice under unstressed and stressed conditions.About:
This article is published in Pharmacological Reports.The article was published on 2011-05-01. It has received 97 citations till now. The article focuses on the topics: Thymoquinone.read more
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A review on therapeutic potential of Nigella sativa: A miracle herb
Aftab Ahmad,Asif Husain,Mohd Mujeeb,Shah Alam Khan,Abul Kalam Najmi,Nasir Ali Siddique,Zoheir A. Damanhouri,Firoz Anwar +7 more
TL;DR: A detailed survey of the literature on scientific researches of pharmacognostical characteristics, chemical composition and pharmacological activities of the seeds of this plant is provided.
Journal ArticleDOI
Thymoquinone and its therapeutic potentials.
Sara Darakhshan,Sara Darakhshan,Ali Bidmeshki Pour,Abasalt Hosseinzadeh Colagar,Sajjad Sisakhtnezhad +4 more
TL;DR: Report on and analyze numerous properties of the active ingredient of N. sativa seeds, TQ, in the context of its therapeutic potentials for a wide range of illnesses and summarize the drug's possible mechanisms of action.
Journal ArticleDOI
Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses.
TL;DR: The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.
Journal ArticleDOI
Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects.
TL;DR: Results of various studies have demonstrated that the oil, extracts, and their active ingredients, in particular, thymoquinone, possess antinociceptive andAnti-inflammatory effects, supporting the common folk perception of N. Sativa as a potent analgesic and anti-inflammatory agent.
Journal ArticleDOI
Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects
TL;DR: Multiple studies made in the last decades validate its health beneficial effects particularly in diabetes, dyslipidemia, hypertension, respiratory disorders, inflammatory diseases, and cancer.
References
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Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Laura C. Green,David A. Wagner,Joseph A. Glogowski,Paul L. Skipper,John S. Wishnok,Steven R. Tannenbaum +5 more
TL;DR: A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described.
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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
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Glutamate, nitric oxide and cell-cell signalling in the nervous system
TL;DR: In this paper, it was shown that NO is produced enzymatically in postsynaptic structures in response to activation of excitatory amino acid receptors and diffuses out to act on neighbouring cellular elements, probably presynaptic nerve endings and astrocyte processes.
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International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
Eric A. Barnard,P. Skolnick,Richard W. Olsen,H. Mohler,W. Sieghart,G. Biggio,C. Braestrup,A. N. Bateson,S. Z. Langer +8 more
TL;DR: This article does not aim to review in detail the properties of γ-aminobutyric acidA(GABAA)breceptors, but in this same journal, a review of the binding properties and pharmacology of these receptors has been published.
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Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
TL;DR: The increased exploratory activity with benzodiazepines does not appear to be a non-specific increase in general motor activity, as locomotion in clonazepam and chlordiazepoxide treated mice placed in a bare, undifferentiated cage was not significantly different from vehicle treated mice.
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Badreldin H. Ali,Gerald Blunden +1 more