Journal ArticleDOI
TNF receptor subtype signalling: differences and cellular consequences.
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TLDR
This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.About:
This article is published in Cellular Signalling.The article was published on 2002-06-01. It has received 610 citations till now. The article focuses on the topics: Cytokine & Signal transduction.read more
Citations
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
TL;DR: This review will focus on the role of the main cytokines, chemokines, and their receptors in the pathophysiology of auto-inflammatory disorders, pro- inflammatory disorders, and neurological disorders involving inflammation.
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The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.
TL;DR: The cytokine network in OA is put in the context of cells involved in this degenerative joint disease and the possibilities for further implementation of new therapeutic strategies are pointed.
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Inflammatory Cytokines and Postmyocardial Infarction Remodeling
TL;DR: The insightful modulation of cytokines through current and future therapies could promote improved healing and cardiac remodeling postmyocardial infarction.
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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
Melissa K. McCoy,Malú G. Tansey +1 more
TL;DR: If inactivation of TNF-dependent inflammation in the brain is warranted by additional pre-clinical studies, selective targeting of TNFR1-mediated signaling while sparing TNFR2 activation may lessen adverse effects of anti-TNF therapies in the CNS.
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Evidence for a cytokine model of cognitive function
TL;DR: The identified central role of cytokines in various brain activities during health provides greater insight into normal brain functions, especially synaptic plasticity, memory and cognition, and facilitates the understanding of specific biological mechanisms involved in neuropsychiatric diseases, such as dementia and depression.
References
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Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
TL;DR: The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells.
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Caspases: the executioners of apoptosis
TL;DR: The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules, such as RAIDD [receptor-interacting protein (RIP)-associated ICH-1/CED-3-homologous protein with a death domain]/CRADD (caspase and RIP adapter with death domain), which binds to the prodomain of cspase-2 and recruits it to the signalling complex.
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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
TL;DR: It is becoming clear that agonist-induced hydrolysis of other membrane phospholipids, particularly choline phospholipsids, by phospholIPase D and phospholiptase A2 may also take part in cell signaling.