Journal ArticleDOI
To kill two birds with one stone: a general concept in gene regulation?
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TLDR
Two recent papers demonstrated the role of bifunctional transcription factors, such as NC2 (Dr1-Drap1), in the broader context of genetic network regulation, and the existence of shared activating sequences will certainly raise several fundamental questions about computational strategies designed to identify gene regulatory sequences.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2001-03-01. It has received 2 citations till now. The article focuses on the topics: Upstream activating sequence & Downstream promoter element.read more
Citations
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Enhancement of the stability of genetic switches by overlapping upstream regulatory domains.
TL;DR: The results suggest that robustness against biochemical noise can provide a selection pressure that drives operons together in the course of evolution.
Dissertation
Significant Pattern Discovery in Gene Location and Phylogeny
TL;DR: This research has revealed effective methods for the analysis of, and has discovered patterns of order in the locations of genes within genomes, in a broad database of phylogenetic trees.
References
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Journal ArticleDOI
A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression.
TL;DR: The results suggest that, in certain chromosomal expression domains, an UAS can affect the transcription of genes that are not immediately downstream from it.
Journal ArticleDOI
A Basal Transcription Factor That Activates or Represses Transcription
TL;DR: The studies reveal that NC2 (Dr1-Drap1) is a bifunctional basal transcription factor that differentially regulates gene transcription through DPE or TATA box motifs.