Transgenesis and paratransgenesis to control insect-borne diseases: current status and future challenges.
TLDR
The current status of transgenesis and paratransgenesis is highlighted, pointing out advantages and constraints, and issues that need to be resolved are explored before the establishment of transGenesis andParatransGenesis as tools to prevent vector-borne diseases.About:
This article is published in Parasitology International.The article was published on 2010-03-01 and is currently open access. It has received 151 citations till now. The article focuses on the topics: Paratransgenesis & Genetically modified insect.read more
Citations
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The gut microbiota of insects - diversity in structure and function.
Philipp Engel,Nancy A. Moran +1 more
TL;DR: Gut bacteria of other insects have also been shown to contribute to nutrition, protection from parasites and pathogens, modulation of immune responses, and communication, and the extent of these roles is still unclear and awaits further studies.
Journal ArticleDOI
Dynamic gut microbiome across life history of the malaria mosquito Anopheles gambiae in Kenya.
TL;DR: Gut community structure was similar in the adult stage between the field and laboratory mosquitoes, indicating that mosquito gut is a selective eco-environment for its microbiome, and suggests a concerted symbiotic genetic association between gut inhabitants and host.
Journal ArticleDOI
Diversity and function of bacterial microbiota in the mosquito holobiont.
TL;DR: A review of the diversity and functions of mosquito-associated bacteria across multiple variation factors, emphasizing recent findings, is presented.
Journal ArticleDOI
Fighting malaria with engineered symbiotic bacteria from vector mosquitoes
Sibao Wang,Anil K. Ghosh,Nicholas J. Bongio,Kevin A. Stebbings,Kevin A. Stebbings,David J. Lampe,Marcelo Jacobs-Lorena +6 more
TL;DR: The use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito is demonstrated, providing the foundation for the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria.
Journal ArticleDOI
Insect natural products and processes: New treatments for human disease
TL;DR: In this overview, some of the more significant recent developments in bioengineering natural products from insects with use or potential use in modern medicine are described, as well as in utilisation of insects as models for studying essential mammalian processes such as immune responses to pathogens.
References
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Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti
Conor J. McMeniman,Roxanna V Lane,Bodil N. Cass,Amy W. C. Fong,Manpreet Sidhu,Yu-Feng Wang,Yu-Feng Wang,Scott Leslie O'Neill +7 more
TL;DR: The data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses.
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Insect population control using a dominant, repressible, lethal genetic system.
TL;DR: A major modification to the sterile insect technique is described, in which transgenic insects homozygous for a dominant, repressible, female-specific lethal gene system are used.
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Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite
TL;DR: The use of genetic manipulation tools to generate transgenic mosquitoes that express antiparasitic genes in their midgut epithelium are reported, thus rendering them inefficient vectors for the disease.
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Selfish DNA: A Sexually-Transmitted Nuclear Parasite
TL;DR: A quantitative population genetics model for the evolution of transposable genetic elements is developed and shows that "selfish" DNA sequences do not have to be selectively neutral at the organismic level; indeed, such DNA can produce major deleterious effects in the host organism and still spread through the population.
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Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique.
Marc J. B. Vreysen,Khalfan M. Saleh,Mashavu Y. Ali,Abdulla M. Abdulla,Zeng-Rong Zhu,Kassim G. Juma,V. Arnold Dyck,Atway R. Msangi,Paul A. Mkonyi,H. Udo Feldmann +9 more
TL;DR: The apparent density of the indigenous fly population declined rapidly in the last quarter of 1995, followed by a population crash in the beginning of 1996, and time for 6 fly generations elapsed between the last catch of an indigenous fly and the end of the sterile male releases in December 1997.
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