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Transition metal catalyzed nucleophilic allylic substitution: activation of allylic alcohols via π-allylic species
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TLDR
Direct activation of allylic alcohols in the presence of transition metal catalysts leading to electrophilic π-allyl metal intermediates represents such a promising target in the field of nucleophilic allylation reactions.Abstract:
Modern organic synthesis now requires efficient atom economical synthetic methods operating under greener pathways to achieve C–C and C–heteroatom bond formation. Direct activation of allylic alcohols in the presence of transition metal catalysts leading to electrophilic π-allyl metal intermediates represents such a promising target in the field of nucleophilic allylation reactions. During the last decade, this topic of recognized importance has become an emerging area, and selected transition metals, sometimes associated with alcohol activators, have brought elegant solutions for performing allylic substitution directly from alcohols in a regio, stereo and enantioselective manner.read more
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Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
Journal ArticleDOI
Transition metal-catalyzed allylic substitution reactions with unactivated allylic substrates
Nicholas Butt,Wanbin Zhang +1 more
TL;DR: The transition metal-catalyzed allylic substitution of unactivated allylic substrates (allylic alcohols, allylic ethers and allylic amines) is rapidly becoming an important area of research.
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New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines.
TL;DR: This review aims to provide a concise overview of modern transition-metal catalyzed approaches to alkylamine synthesis and their functionalization.
Journal ArticleDOI
Dehydrative Direct CH Allylation with Allylic Alcohols under [Cp*CoIII] Catalysis
Yudai Suzuki,Bo Sun,Ken Sakata,Tatsuhiko Yoshino,Tatsuhiko Yoshino,Shigeki Matsunaga,Shigeki Matsunaga,Motomu Kanai +7 more
TL;DR: A cationic [Cp*Co(III)] catalyst promoted direct dehydrative C-H allylation with non-activated allyl alcohols, thus giving C2-allylated indoles, pyrrole, and phenyl-pyrazole in good yields, while analogous catalysts were not effective.
Journal ArticleDOI
Recent approaches for C–C bond formation via direct dehydrative coupling strategies
TL;DR: This review article aims to highlight advances in such waste-free C-C bond forming dehydrative strategies devised for the direct dehydrative coupling employing the C-OH bond.
References
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Journal ArticleDOI
Asymmetric Transition Metal-Catalyzed Allylic Alkylations.
TL;DR: The focus of this review is on the area of enantioselective transition metal-catalyzed allylic alkylations which may involve C-C as well as C-X (X ) H or heteroatom) bond formation.
Journal ArticleDOI
PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis
Günter Helmchen,Andreas Pfaltz +1 more
TL;DR: Chiral phosphinooxazolines (PHOX ligands) as discussed by the authors coordinate to a metal center with a N-and a P-atom, allowing effective enantiocontrol in a variety of metal-catalyzed reactions.
Journal ArticleDOI
Green chemistry for chemical synthesis
Chao-Jun Li,Barry M. Trost +1 more
TL;DR: Green chemistry for chemical synthesis addresses the future challenges in working with chemical processes and products by inventing novel reactions that can maximize the desired products and minimize by-products.
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