Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?
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In this paper , the authors review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigmms and methods for assessing the state of the endocannaloid system in PTSD.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2022-01-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Endocannabinoid system & Extinction (optical mineralogy).read more
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The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD
TL;DR: In this article , the authors examined whether genetic variation in the FAAH gene (C385A; rs324420) influences physiological, cognitive, and neural indices of fear acquisition and extinction learning among a sample of adult women with PTSD.
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Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice
TL;DR: In this article , the effects of activation of PKA by systemic application of rolipram or meglumine cyclic adenosine 3,5-monophosphate (cAMP)-protein kinase A (PKA), protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and calcium signaling in peripheral serum of PTSD patients using bioinformatics analysis were shown.
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Methodological implications of sample size and extinction gradient on the robustness of fear conditioning across different analytic strategies
Luke J. Ney,Patrick A.F. Laing,Trevor Steward,Daniel V. Zuj,Simon Dymond,Ben J. Harrison,Bronwyn M. Graham,Kim L Felmingham +7 more
TL;DR: In this paper , the authors investigated the effect of variance in sample size on the performance of different kinds of fear conditioning analyses and found that confounds incurred by inconsistent analyses remain stable in the face of sample size variation, but only under specific circumstances with overall robustness strongly hinging on the relationship between experimental design and choice of analyses.
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Angry and fearful compared to happy or neutral faces as conditional stimuli in human fear conditioning: A systematic review and meta-analysis
TL;DR: A systematic review and meta-analysis of fear conditioning studies comparing face conditional stimuli (CS) of differing expressions identified thirty studies, eighteen of which were eligible for meta analysis as mentioned in this paper .
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Circulating endocannabinoids and psychological outcomes in women with PTSD.
Chloe Botsford,Angelique G. Brellenthin,Josh M. Cisler,Cecilia J. Hillard,Kelli F. Koltyn,Kevin M. Crombie +5 more
TL;DR: A subset of data was pooled from five studies in which women with and without PTSD (N = 98) completed questionnaires related to mood states and a blood draw prior to and following a bout of moderate-intensity aerobic exercise in order to determine: 1) whether circulating eCBs differ between groups and whether depressive and PTSD symptom severity are associated with baseline eCB, 2) whether a couple of hours of moderate intensity aerobic exercise significantly increased circulating ECA in adult women with PTSD, and 3) whether the circulating eCA and 2-arachidonoylethanolamine (AEA) were associated with overall mood states as discussed by the authors .
References
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