Journal ArticleDOI
Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis.
Odd Nygård,Lennart Nilsson +1 more
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This article is published in FEBS Journal.The article was published on 1990-07-20. It has received 168 citations till now. The article focuses on the topics: Translational regulation & Eukaryotic Small Ribosomal Subunit.read more
Citations
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Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
Harold B.J. Jefferies,Stefano Fumagalli,Patrick B. Dennis,Christoph Reinhard,Richard B. Pearson,George Thomas +5 more
TL;DR: It is demonstrated that an intact polypyrimidine tract is required for rapamycin to elicit an inhibitory effect on the translation of mRNAs encoding ribosomal proteins and elongation factors.
Journal ArticleDOI
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.
Igor Ruvinsky,Oded Meyuhas +1 more
TL;DR: It seems that establishing the function of the phosphorylation of other effectors of mTOR or S6K will inevitably require genetic manipulation of the respective sites within these targets.
Journal ArticleDOI
Ribosomal S6 Kinase Signaling and the Control of Translation
Almut Dufner,George Thomas +1 more
TL;DR: The present state of knowledge regarding upstream signaling components which have been implicated in the control of S6K1 activation and the role of the kinase in controlling cell growth through regulating ribosome biogenesis at the translational level is discussed.
Journal ArticleDOI
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
TL;DR: Analysis of individual mRNA transcripts revealed that rapamycin selectively suppresses the translation of a family of mRNAs that is characterized by a polypyrimidine tract immediately after their N7-methylguanosine cap, a motif that can act as a translational modulator.
Journal ArticleDOI
Mechanism and regulation of eukaryotic protein synthesis.
TL;DR: This review presents a description of the numerous eukaryotic protein synthesis factors and their apparent sequential utilization in the processes of initiation, elongation, and termination and the rare use of reinitiation and internal initiation.
References
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Journal ArticleDOI
The scanning model for translation: an update.
TL;DR: The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.
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The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites
John Shine,Lynn Dalgarno +1 more
TL;DR: It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons.
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The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.
TL;DR: The findings indicate that the toxin inactivates the ribosomes by modifying both or either of two nucleoside residues, G4323 and A4324, in 28 S rRNA, in a general mechanistic pathway for ribosome inactivation by lectin toxins.
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Structure of ribosomal rna
TL;DR: The primary structure of rRNA Species-Nomenclature and the secondary structure of Secondary-Structure are investigated in more detail in this chapter.
Journal ArticleDOI
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.
Peter Walter,Gonter Blobel +1 more
TL;DR: It is concluded that the interaction of SRP with the amino-terminal signal peptide of the nascent chain (emerged from the large ribosomal subunit) that modulates translation and thereby causes an arrest in chain elongation.