Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity.
TLDR
The hemagglutinating activity of transmissible gastroenteritis virus (TGEV), an enteric porcine coronavirus, was analyzed and found to be dependent on the presence of alpha-2,3-linked sialic acid on the erythrocyte surface, suggesting that the sIALic acid binding site is blocked by virus-associated competitive inhibitors.Citations
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Journal ArticleDOI
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
Journal ArticleDOI
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein
TL;DR: This review discusses coronavirus entry mechanisms focusing on the different triggers used by coronaviruses to initiate the conformational change of the S protein: receptor binding, low pH exposure and proteolytic activation.
Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structural basis for human coronavirus attachment to sialic acid receptors.
M. Alejandra Tortorici,M. Alejandra Tortorici,M. Alejandra Tortorici,Alexandra C. Walls,Yifei Lang,Chunyan Wang,Zeshi Li,Danielle Koerhuis,Geert-Jan Boons,Berend Jan Bosch,Félix A. Rey,Félix A. Rey,Raoul J. de Groot,David Veesler +13 more
TL;DR: The results demonstrate these viruses evolved similar strategies to engage sialoglycans at the surface of target cells, and how 9-O-acetyl sialic acid is recognized by the human coronavirus OC43 S glycoprotein and how this interaction promotes viral entry.
Book ChapterDOI
Host Factors in Coronavirus Replication.
TL;DR: This review summarizes the current understanding of coronavirus–host interactions at the level of the infected cell, with special attention for the assembly and function of the viral RNA-synthesising machinery and the evasion of cellular innate immune responses.
References
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Journal ArticleDOI
Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV.
TL;DR: It is reported that aminopeptidase N, an ectoenzyme abundantly expressed at the apical membrane of the enterocytes, serves as a receptor for Transmissible gastroenteritis virus.
Journal ArticleDOI
Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.
TL;DR: Results suggest that, like influenza C viruses, human coronav virus OC43 and bovine coronavirus recognize O-acetylated sialic acid or a similar derivative as cell receptor.
Journal ArticleDOI
Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis.
M Pensaert,P Callebaut,J Vergote +2 more
TL;DR: A porcine respiratory, non-enteric virus which is related to the coronavirus transmissible gastroenteritis virus (TGEV) has been isolated in pigs and in cell culture and is assumed to be a new TGEV-related porcines respiratory coronav virus which has totally lost its tropism for the enteric tract.
Journal ArticleDOI
The S protein of bovine coronavirus is a hemagglutinin recognizing 9-O-acetylated sialic acid as a receptor determinant.
TL;DR: The S protein of bovine coronavirus has been isolated from the viral membrane and purified by gradient centrifugation and the potential of S protein as a probe for the detection of Neu5,9Ac2-containing glycoconjugates is demonstrated.
Journal ArticleDOI
Genetic evolution and tropism of transmissible gastroenteritis coronaviruses
TL;DR: The genetic relationship among six European PRCVs and five coronaviruses of the TGEV antigenic cluster has been determined based on their RNA sequences and a significant constancy in the fixation of mutations with time showed the existence of a well-defined molecular clock.