Journal ArticleDOI
Transparency throughout the production chain : a way to reduce pollution from the manufacturing of pharmaceuticals?
D. G. Joakim Larsson,Jerker Fick +1 more
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TLDR
Investigation of the origin of active pharmaceutical ingredients in 242 selected products on the Swedish market found that the APIs in 71 products originated from Indian manufacturers sending their waste to a treatment plant where unprecedented amount of environmental pollution with broad-spectrum antibiotics and other drugs recently has been documented.About:
This article is published in Regulatory Toxicology and Pharmacology.The article was published on 2009-04-01. It has received 95 citations till now. The article focuses on the topics: Environmental pollution.read more
Citations
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Pharmaceuticals and personal care products in the aquatic environment in China: a review.
TL;DR: The results of SLERA revealed that the hot spots for PPCP pollution were those river waters affected by the megacities with high density of population, such as Beijing, Tianjin, Guangzhou and Shanghai.
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Contamination of surface, ground, and drinking water from pharmaceutical production.
Jerker Fick,Hanna Söderström,Richard H. Lindberg,Chau Phan,Mats Tysklind,D. G. Joakim Larsson +5 more
TL;DR: In this paper, the authors investigated the environmental fate of active pharmaceutical ingredients in a major production area for the global bulk drug market, where water samples were taken from a common effluent treatment plant near Hyderabad, India, which receives process water from approximately 90 bulk drug manufacturers.
Pharmaceuticals and Personal Care Products in the Environment CONTAMINATION OF SURFACE, GROUND, AND DRINKING WATER FROM PHARMACEUTICAL PRODUCTION
TL;DR: In this article, the authors investigated the environmental fate of active pharmaceutical ingredients in a major production area for the global bulk drug market, where water samples were taken from a common effluent treatment plant near Hyderabad, India, which receives process water from approximately 90 bulk drug manufacturers.
Journal ArticleDOI
Management Options for Reducing the Release of Antibiotics and Antibiotic Resistance Genes to the Environment
Amy Pruden,D. G. Joakim Larsson,Alejandro Amézquita,Peter Collignon,Kristian K. Brandt,David W. Graham,James M. Lazorchak,Satoru Suzuki,Peter Silley,Jason Snape,Edward Topp,Tong Zhang,Yong-Guan Zhu +12 more
TL;DR: Environmental releases of antibiotics and antibiotic-resistant bacteria can in many cases be reduced at little or no cost and the anticipated benefit is an extended useful life span for current and future antibiotics.
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Pharmaceutical Industry Wastewater: Review of the Technologies for Water Treatment and Reuse
Chandrakanth Gadipelly,A. Pérez-González,Ganapati D. Yadav,Inmaculada Ortiz,Raquel Ibañez,Virendra K. Rathod,Kumudini V. Marathe +6 more
TL;DR: The use of conventional treatment methods along with membrane reactors and advanced posttreatment methods resulting in a hybrid wastewater treatment technology appear to be the best and will prove useful for treatment of wastewater from the pharmaceutical industry.
References
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Journal ArticleDOI
Antibiotics and antibiotic resistance genes in natural environments.
TL;DR: The large majority of antibiotics currently used for treating infections and the antibiotic resistance genes acquired by human pathogens each have an environmental origin and the function of these elements in their environmental reservoirs may be very distinct from the “weapon-shield” role they play in clinical settings.
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Effluent from drug manufactures contains extremely high levels of pharmaceuticals
TL;DR: Analysis of pharmaceuticals in the effluent from a wastewater treatment plant serving about 90 bulk drug manufacturers in Patancheru, near Hyderabad, India suggests an increased focus on the potential release of active pharmaceutical ingredients from production facilities in different regions.
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Pharmaceuticals in the Environment
TL;DR: For example, the authors found that pharmaceutical concentrations in the aquatic environment are in the same range (μg L−1 and below); however, it is not clear whether this holds for less developed countries too.
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Occurrence and distribution of pharmaceutical organic compounds in the groundwater downgradient of a landfill (grindsted, denmark).
TL;DR: The occurrence and distribution of organic compounds originating from waste from the pharmaceutical industry in the groundwater downgradient of the same landfill is described, the first report on pharmaceutical compounds in a leachate plume.
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Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river.
TL;DR: This study investigated the occurrence and fate of oxytetracycline (OTC) and its related substances, 4-epi-oxytetracyCline (EOTC), alpha-apo-oxytracy Cline (alpha-apo)-OTC, and beta-apo (beta-apo) in a wastewater treatment plant treating OTC production wastewater and a river receiving the effluent from the WWTP using liquid chromatography electrospray ionization mass spect