Journal ArticleDOI
Treatment of knee osteoarthritis by intra-articular injection of concentrated autologous adipose tissue: a twenty four month follow-up study
Alessandro Bistolfi,Ilaria Roato,Giulia Fornelli,Luigi Sabatini,Alessandro Massè,Riccardo Ferracini +5 more
TLDR
In this paper, the authors evaluated the safety and efficacy of autologous concentrated adipose tissue for the treatment of knee OA and found that a single intra-articular injection of the tissue reduced knee pain, stiffness, improved knee function and quality of life without severe complications.Abstract:
To evaluate the safety and efficacy of autologous concentrated adipose tissue for the treatment of knee OA. Eighty-seven patients with knee arthritis from grade 1 to 3, according to Kellgren-Lawrence scale, have been treated with knee arthroscopy and successive intra-articular injection of concentrated adipose tissue. The efficacy of the treatment has been evaluated by the Knee Society Score, Lysholm Score, Forgotten Joint Score, Knee Injury and Osteoarthritis Outcome Score and Noise Reporting Scale. A total of 78/87 patients concluded the study. Overall, the patients were satisfied with the intervention and a significant reduction of the pain was observed in 67 patients, while the others did not report any change in pain severity or worsening. A statistically significant improvement was observed in the considered orthopaedic index, and no major adverse effects were described. The first week after the intervention, most patients reported knee swelling. Five patients failed because they underwent knee replacement surgery between five and nine months from treatment. In patients with knee OA, a single intra-articular injection of autologous adipose tissue reduced knee pain, stiffness, improved knee function and quality of life without severe complications.read more
Citations
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Journal ArticleDOI
Post-Adipose-Derived Stem Cells (ADSC) Stimulated by Collagen Type V (Col V) Mitigate the Progression of Osteoarthritic Rabbit Articular Cartilage.
I. B. Cruz,Ana Paula Pereira Velosa,Solange Carrasco,Antonio dos Santos Filho,Jurandir Tomaz de Miranda,Eduardo Pompeu,Tiago Fernandes,Daniela Franco Bueno,Camila Fanelli,Claudia Goldenstein-Schainberg,Alexandre Todorovic Fabro,Ricardo Fuller,Pedro L. Silva,Pedro L. Silva,Vera Luiza Capelozzi,Walcy Rosolia Teodoro +15 more
TL;DR: In this article, the effects of type V collagen on the proliferation and differentiation of ADSC were investigated in vitro, and the expression of the cartilage-related genes Col2a1 and Acan was significantly upregulated and Pou5fl was downregulated post-ADSC/Col V treatment.
Journal ArticleDOI
Methodological Flaws in Meta-Analyses of Clinical Studies on the Management of Knee Osteoarthritis with Stem Cells: A Systematic Review
Christoph Dipl.-Ing. Schmitz,Christopher Alt,David A. Pearce,John P. Furia,Nicola Maffulli,Eckhard Alt +5 more
TL;DR: Clinicians should interpret the results of the 19 assessed meta-analyses of clinical studies on the management of primary knee osteoarthritis with stem cells with caution and should be cautious of the conclusions drawn therein.
Journal ArticleDOI
Intra-Articular Administration of Autologous Purified Adipose Tissue Associated with Arthroscopy Ameliorates Knee Osteoarthritis Symptoms.
Marco Caforio,Carmelo G A Nobile +1 more
TL;DR: In this article, the authors evaluated the safety and efficacy of the intra-articular administration of autologous purified adipose tissue to treat knee osteoarthritis following arthroscopy.
Journal ArticleDOI
Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study
Trivia Frazier,Keith L. March,Jaime R. Garza,Bruce A. Bunnell,K. Darr,Emma Rogers,Katie Hamel,Jeffrey M. Gimble +7 more
TL;DR: In this paper , a review of the regulatory landscape governing the utilization of autologous and allogeneic adipose tissue remains complex, and the FDA's nomenclature and guidance regarding adipose products are discussed.
Journal ArticleDOI
Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue
Riccardo Ferracini,Mattia Alessio-Mazzola,Beatrice Sonzogni,C Stambazzi,Chiara Ursino,Ilaria Roato,Federico Mussano,Alessandro Bistolfi,Sérgio Furlan,Laura Godio,Daniela Alotto,Matteo Formica +11 more
TL;DR: In this paper , the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and whether patients' pre-treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment.
References
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How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up.
Jonathan Evans,Jonathan P Evans,Robert W Walker,Ashley W Blom,Ashley W Blom,Michael R Whitehouse,Michael R Whitehouse,Adrian Sayers +7 more
TL;DR: Patients and surgeons can expect a hip replacement to last 25 years in around 58% of patients, assuming that estimates from national registries are less likely to be biased.
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