TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
Sarah R. Wilson,Kristin A. Gerhold,Amber Bifolck-Fisher,Qin Liu,Kush N. Patel,Xinzhong Dong,Diana M. Bautista +6 more
TLDR
Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders and the findings indicate that TRPA1 is an essential component of the signaling pathways that promote histamine-independent itch.Citations
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Dmitry Usoskin,Alessandro Furlan,Saiful Islam,Hind Abdo,Peter Lönnerberg,Daohua Lou,Jens Hjerling-Leffler,Jesper Z. Haeggström,Olga Kharchenko,Peter V. Kharchenko,Sten Linnarsson,Patrik Ernfors +11 more
TL;DR: The results suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a distinct itch-generating type, and demonstrate single-cell RNA-seq as an effective strategy for dissecting sensory responsive cells into distinct neuronal types.
Journal ArticleDOI
TRP Channels and Pain
TL;DR: Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli and is providing insight into the coding logic of nnociception and how specification of nOCiceptor subtypes underlies behavioral discrimination ofNoxious thermal, chemical, and mechanical stimuli.
Journal ArticleDOI
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Sarah R. Wilson,Sarah R. Wilson,Lyn Batia,Katherine Beattie,George E. Katibah,Shannan P. McClain,Maurizio Pellegrino,Daniel Estandian,Diana M. Bautista,Diana M. Bautista +9 more
TL;DR: The results support a model whereby calcium-dependent TSLP release by keratinocytes activates both primary afferent neurons and immune cells to promote inflammatory responses in the skin and airways.
Journal ArticleDOI
Chimeric antigen receptor-modified T cells derived from defined CD8 + and CD4 + subsets confer superior antitumor reactivity in vivo
Daniel Sommermeyer,Michael Hudecek,Michael Hudecek,Paula L. Kosasih,Tea Gogishvili,David G. Maloney,David G. Maloney,Cameron J. Turtle,Cameron J. Turtle,Stanley R. Riddell,Stanley R. Riddell,Stanley R. Riddell +11 more
TL;DR: It is shown that CAR-T-cell products generated from defined T-cell subsets can provide uniform potency compared with products derived from unselected T cells that vary in phenotypic composition.
Journal ArticleDOI
Structure of the TRPA1 ion channel suggests regulatory mechanisms
TL;DR: Single-particle electron cryo- microscopy is used to determine the structure of full-length human TRPA1 to ∼4 Å resolution and establish a blueprint for structure-based design of analgesic and anti-inflammatory agents.
References
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Journal ArticleDOI
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt,Diana M. Bautista,Huai-hu Chuang,David D. McKemy,Peter M. Zygmunt,Edward D. Högestätt,Ian D. Meng,Ian D. Meng,David Julius +8 more
TL;DR: It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana.
Journal ArticleDOI
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
Diana M. Bautista,Sven-Eric Jordt,Tetsuro Nikai,Pamela R. Tsuruda,Andrew J. Read,Jeannie Poblete,Ebenezer N. Yamoah,Allan I. Basbaum,David Julius +8 more
TL;DR: Using TRPA1-deficient mice, it is shown that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain.
Journal ArticleDOI
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Michael Bandell,Gina M. Story,Sun Wook Hwang,Veena Viswanath,Samer R. Eid,Matt Petrus,Taryn J. Earley,Ardem Patapoutian,Ardem Patapoutian +8 more
TL;DR: It is demonstrated that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
Journal ArticleDOI
TRPA1 mediates formalin-induced pain
Colleen Mcnamara,Josh Mandel-Brehm,Diana M. Bautista,Jan Siemens,Kari L. Deranian,Michael Zhao,Neil Hayward,Jayhong A. Chong,David Julius,Magdalene M. Moran,Christopher M. Fanger +10 more
TL;DR: It is shown that TRPA1 is the principal site of formalin's pain-producing action in vivo, and that activation of this excitatory channel underlies the physiological and behavioral responses associated with this model of pain hypersensitivity.
Journal ArticleDOI
The neurobiology of itch
TL;DR: Current research concentrates on the identification of common targets for future analgesic and antipruritic therapy, and there is a broad overlap between pain- and itch-related peripheral mediators and/or receptors.
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A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Yan-Gang Sun,Zhou-Feng Chen +1 more