Journal ArticleDOI
Tumor necrosis factor (TNF)
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This article is published in Science.The article was published on 1985-11-08. It has received 2505 citations till now. The article focuses on the topics: Recombinant tumor necrosis factor & Tumor necrosis factor alpha.read more
Citations
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
Journal ArticleDOI
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
TL;DR: A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA.
Journal ArticleDOI
Global initiative for chronic obstructive lung disease.
Lynn B. Gerald,William C. Bailey +1 more
TL;DR: Representatives from many countries serve as a network for the dissemination and implementation of programs for diagnosis, management, and prevention of COPD.
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Naoto Itoh,Shin Yonehara,Ai Ishii,Minako Yonehara,Sei Ichi Mizushima,Masazumi Sameshima,Atsushi Hase,Yoshiyuki Seto,Shigekazu Nagata +8 more
TL;DR: Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells and revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain.
Journal ArticleDOI
The anti-inflammatory effect of exercise
TL;DR: It is suggested that myokines may be involved in mediating the health-beneficial effects of exercise and that these in particular are involved in the protection against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases.
References
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Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
Journal ArticleDOI
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
Diane Pennica,Glenn Evan Nedwin,Joel S. Hayflick,Peter H. Seeburg,Rik Derynck,Michael A. Palladino,William J. Kohr,Bharat B. Aggarwal,David V. Goeddel +8 more
TL;DR: Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
Journal ArticleDOI
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.
Bruce Beutler,D. Greenwald,J. D. Hulmes,M. Chang,Yu-Ching E. Pan,John C. Mathison,Richard J. Ulevitch,Anthony Cerami +7 more
TL;DR: It is suggested that the ‘cachectin’ and ‘TNF’ activities of murine macrophage conditioned medium are attributable to a single protein, which modulates the metabolic activities of normal as well as neoplastic cells through interaction with specific high-affinity receptors.
Journal Article
Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.
M R Shalaby,Bharat B. Aggarwal,E Rinderknecht,L. P. Svedersky,B. S. Finkle,Michael A. Palladino +5 more
TL;DR: Although lipopolysaccharide (LPS) is a potent stimulator of PMN function, polymyxin B can block LPS-induced but not lymphokine-induced activation, demonstrating new activities for both TNF-alpha and T NF-beta in augmenting the phagocytic and cytotoxic activities of PMn.
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Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.
TL;DR: The purification of cachectin to apparent homogeneity and characterization of its receptor should facilitate further investigations into the role of Cachectin and other macrophage mediators in the metabolic derangements that occur during infection and cachexia.
Related Papers (5)
Cachectin and tumour necrosis factor as two sides of the same biological coin
Bruce Beutler,Anthony Cerami +1 more