Journal ArticleDOI
Two cortical systems for memory-guided behaviour
Charan Ranganath,Maureen Ritchey +1 more
TLDR
It is suggested that the PRC and PHC–RSC are core components of two separate large-scale cortical networks that are dissociable by neuroanatomy, susceptibility to disease and function.Abstract:
Although the perirhinal cortex (PRC), parahippocampal cortex (PHC) and retrosplenial cortex (RSC) have an essential role in memory, the precise functions of these areas are poorly understood. Here, we review the anatomical and functional characteristics of these areas based on studies in humans, monkeys and rats. Our Review suggests that the PRC and PHC-RSC are core components of two separate large-scale cortical networks that are dissociable by neuroanatomy, susceptibility to disease and function. These networks not only support different types of memory but also appear to support different aspects of cognition.read more
Citations
More filters
Journal ArticleDOI
The default network and self-generated thought: component processes, dynamic control, and clinical relevance
TL;DR: Evidence is presented that self‐generated thought is a multifaceted construct whose component processes are supported by different subsystems within the network, and clinical implications of disruptions to the integrity of the network are discussed.
Journal ArticleDOI
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
Journal ArticleDOI
Long-axis specialization of the human hippocampus
TL;DR: It is suggested that various long-axis specializations arise out of differences between the anterior and posterior hippocampus in large-scale network connectivity, the organization of entorhinal grid cells, and subfield compositions that bias the aHPC and pHPC towards pattern completion and separation, respectively.
Journal ArticleDOI
Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation
TL;DR: Using the component process model as a framework, and focusing on the hippocampus, its subfields, and specialization along its longitudinal axis, along with its interaction with other brain regions, this work considers these new developments and their implications for the organization of episodic memory and its contribution to functions in other domains.
Journal ArticleDOI
Discovering Event Structure in Continuous Narrative Perception and Memory
Christopher Baldassano,Janice Chen,Asieh Zadbood,Jonathan W. Pillow,Uri Hasson,Kenneth A. Norman +5 more
TL;DR: It is proposed that brain activity is naturally structured into nested events, which form the basis of long-term memory representations, which represent abstract, multimodal situation models.
References
More filters
Journal ArticleDOI
Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
Journal ArticleDOI
A default mode of brain function.
Marcus E. Raichle,Ann Mary MacLeod,Abraham Z. Snyder,William J. Powers,Debra A. Gusnard,Gordon L. Shulman +5 more
TL;DR: A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors.
Journal ArticleDOI
The Brain's Default Network Anatomy, Function, and Relevance to Disease
TL;DR: Past observations are synthesized to provide strong evidence that the default network is a specific, anatomically defined brain system preferentially active when individuals are not focused on the external environment, and for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease.
Journal ArticleDOI
The role of knowledge in discourse comprehension : a construction-integration model
TL;DR: This chapter discusses data concerning the time course of word identification in a discourse context and a simulation of arithmetic word-problem understanding provides a plausible account for some well-known phenomena.
Journal ArticleDOI
The medial temporal lobe memory system
TL;DR: The medial temporal lobe memory system is needed to bind together the distributed storage sites in neocortex that represent a whole memory, but the role of this system is only temporary, as time passes after learning, memory stored in neoc cortex gradually becomes independent of medialporal lobe structures.