Two-dimensional silicon photonic crystal based biosensing platform for protein detection.
Mindy R. Lee,Philippe M. Fauchet +1 more
TLDR
An ultrasensitive two-dimensional photonic crystal microcavity biosensor that can detect a molecule monolayer with a total mass as small as 2.5 fg and measure the redshift corresponding to the binding of glutaraldehyde and bovine serum albumin is demonstrated.Abstract:
We theoretically and experimentally demonstrate an ultrasensitive two-dimensional photonic crystal microcavity biosensor. The device is fabricated on a silicon-on-insulator wafer and operates near its resonance at 1.58 μm. Coating the sensor internal surface with proteins of different sizes produces a different amount of resonance redshift. The present device can detect a molecule monolayer with a total mass as small as 2.5 fg. The device performance is verified by measuring the redshift corresponding to the binding of glutaraldehyde and bovine serum albumin (BSA). The experimental results are in good agreement with theory and with ellipsometric measurements performed on a flat oxidized silicon wafer surface.read more
Citations
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Journal ArticleDOI
Sensitive optical biosensors for unlabeled targets: a review.
TL;DR: This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms, and focuses on the optical biosENSors that utilize the refractive index change as the sensing transduction signal.
Journal ArticleDOI
Whispering-gallery-mode biosensing: label-free detection down to single molecules
Frank Vollmer,Stephen Arnold +1 more
TL;DR: The enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor are described, its current implementations and applications are reviewed, and its future possibilities are discussed.
Journal ArticleDOI
On the performance quantification of resonant refractive index sensors
Ian M. White,Xudong Fan +1 more
TL;DR: A rigorous definition for the detection limit of resonant RI sensors is set forth that accounts for all parameters that affect the detection performance and will lead to design strategies for performance improvement of RI sensors.
Journal ArticleDOI
Optofluidic microsystems for chemical and biological analysis
Xudong Fan,Ian M. White +1 more
TL;DR: The mechanisms by which optofluidics enhances bio/chemical analysis capabilities, including sensing and the precise control of biological micro/nanoparticles, are emphasized.
Journal ArticleDOI
Photonic Crystals for Chemical Sensing and Biosensing
TL;DR: This Review covers photonic crystals and their use for sensing mainly chemical and biochemical parameters, with a particular focus on the materials applied.
References
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High- Q photonic nanocavity in a two-dimensional photonic crystal
TL;DR: A silicon-based two-dimensional photonic-crystal slab is used to fabricate a nanocavity with Q = 45,000 and V = 7.0 × 10-14 cm3; the value of Q/V is 10–100 times larger than in previous studies, underlying the realization that light should be confined gently in order to be confined strongly.
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A Porous Silicon-Based Optical Interferometric Biosensor
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TL;DR: A biosensor has been developed based on induced wavelength shifts in the Fabry-Perot fringes in the visible-light reflection spectrum of appropriately derivatized thin films of porous silicon semiconductors based on Binding of molecules induced changes in the refractive index of the porous silicon.
Book ChapterDOI
Hydration of Proteins and Polypeptides
Irwin D. Kuntz,W. Kauzmann +1 more
TL;DR: The chapter presents several proposals for predicting protein hydration based on the amino acid composition of the protein; however, the two main questions concerned include—whether ionic groups are more hydrated than other polar groups, and whether the amide and peptide functions are hydrated or not.
Journal ArticleDOI
Principles of biosensing with an extended coupling matrix and surface plasmon resonance
TL;DR: In this paper, the surface plasmon resonance angle shifts are calculated as a function of the amount of organic material in the interaction matrix and the influence of physical parameters, such as matrix thickness and wavelength of the light, on the expected performance is considered.
Journal ArticleDOI
Defect Modes of a Two-Dimensional Photonic Crystal in an Optically Thin Dielectric Slab
TL;DR: In this paper, a three-dimensional finite-difference time-domain analysis of localized defect modes in an optically thin dielectric slab that is patterned with a two-dimensional array of air holes is presented.