Journal ArticleDOI
Über aktivierte Ester. I. Aktivierte Ester der Hippursäure und ihre Umsetzungen mit Benzylamin
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TLDR
In this article, a number of activated esters of hippuric acid are compared and the best acylating agent seems to be the cyanomethylester which is an easily accessible, cristalline, and stable compound, reacting easily with benzylamine at room temperature.Abstract:
Introduction of electron-attracting substituents into the alcoholic component of methyl-hippurate leads to activated esters which are characteristic acylating agents. A number of activated esters of hippuric acid are compared. The best acylating agent seems to be the cyanomethylester which is an easily accessible, cristalline, and stable compound, reacting easily with benzylamine at room temperature.read more
Citations
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Journal ArticleDOI
Synthetische Arbeiten in der Reihe der aromatischen Erythrina‐Alkaloide, I. Synthese des racem. trans‐15.16‐Dimethoxy‐erythrinans
TL;DR: In this paper, Dimethoxy-erythrinan last sich durch eine einfache Synthese aus Homoveratrylamin and Cyclohexanon-(2)-essigsaure in guter Ausbeute gewinnen.
Journal ArticleDOI
Die Chemie der Acylcyanide
J. Thesing,D. Witzel,A. Brehm +2 more
TL;DR: Acylcyanide nehmen eine Ubergangsstellung zwischen einfachen Carbonyl-Verbindungen und Acylhalogeniden ein this paper.
Journal ArticleDOI
A new method for the synthesis of α‐esters of N‐acylglutamic acids
G. H. L. Nefkens,R. J. F. Nivard +1 more
TL;DR: In this article, N-Benzyloxycarbonyl, N-tosyl- and N-phthaloylglutamic acids were converted into various α-esters by addition of an equimolecular amount of a base triethylamine or dicyclohexylamine) and treatment with an appropriate alkyl halide or dialkyl sulphate.
Book ChapterDOI
Synthese von Peptiden
W. Grassmann,E. Wünsch +1 more
TL;DR: In this article, aufgefundene Selbstkondensation freier Aminosaureester konnte ihrer Natur nach nur zu Gemischen von undefinierter Kettenlange fuhren.
Journal ArticleDOI
Stepwise synthesis of peptides by the nitrophenyl‐ester method
TL;DR: Recent developments in the study of amino acid composition and sequence in proteins has led to the fascinating elucidation of structures as complex as insulin,1a ACTH,“ glucagon,ls and even of ribonuclease,’6 thereby far outstripping the authors' synthetic capacity.
References
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Journal ArticleDOI
Über Peptidsynthesen. 8. Mitteilung Bildung von S‐haltigen Peptiden durch intramolekulare Wanderung von Aminoacylresten
Book ChapterDOI
The synthesis of peptides
TL;DR: This chapter focuses on the available methods for the synthesis of peptides and evaluates their relative difficulty, their adaptability to meet problems encountered in amino acid chemistry, and the yield and purity of the products of synthesis.
Journal ArticleDOI
Synthese von S‐Lactyl‐ und S‐β‐Oxybutyryl‐glutathionn
Theodor Wieland,Herbert Koppe +1 more
Journal ArticleDOI
Coenzym A: Modellreaktionen zur enzymatischen Aktivierung von Acylderivaten des Coenzyms A
Robert Schwyzer,Ch. Hürlimann +1 more
TL;DR: In this paper, the reactivity of esters of thiolcarboxylic acids with amino compounds is strongly and specifically enhanced by metal ions possessing affinity for the sulfur atom.