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Ultrafiltration for acute decompensated heart failure: cost, reimbursement, and financial impact.

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TLDR
The impact of these various factors is analyzed to better understand how the intensity (and expense) of pharmaceutical and extracorporeal therapies impacts a single admission, as well as to serve as the basis for developing strategies for optimizing long‐term care.
Abstract
In addition to the proposed pathophysiologic mechanisms whereby ultrafiltration (UF) can be advantageous over diuretics in the treatment of heart failure, there can also be financial and resource-utilization reasons for pursuing this extracorporeal strategy. In those cases in which the clinical outcomes would be equivalent, however, the decision whether to pursue UF will depend greatly on the anticipated hospitalization length of stay (LOS), the patient population's pay or mix, the needs and costs for high-acuity (eg, intensive care unit) care, and widely varying expenses for the equipment and disposable supplies. From a fiscal perspective, the financial viability of UF programs revolves around how improvements in LOS, resource utilization, and readmissions relate to the typical diagnosis-driven (eg, diagnosis-related group) reimbursement. We analyzed the impact of these various factors so as to better understand how the intensity (and expense) of pharmaceutical and extracorporeal therapies impacts a single admission, as well as to serve as the basis for developing strategies for optimizing long-term care.

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Journal ArticleDOI

The cardioprotective effect of melatonin and exendin‐4 treatment in a rat model of cardiorenal syndrome

TL;DR: Combined melatonin and exendin‐4 treatment suppressed CRS‐induced deterioration of LVEF and LV remodeling, and biomarkers in LV myocardium showed an opposite pattern compared to that of LVP among all groups.
Journal ArticleDOI

Ultrafiltration therapy for cardiorenal syndrome: physiologic basis and contemporary options.

TL;DR: While extracorporeal ultrafiltration is an appealing therapeutic option for patients with acute decompensated HF, determining the optimal fluid removal rate and the impact on renal function need further investigation.
Journal ArticleDOI

Ultrafiltration for acute decompensated heart failure: financial implications.

TL;DR: A summary of the relevant pathophysiological mechanisms such as removal of inflammatory cytokines are provided that might indeed be associated with a number of financial implications for ultrafiltration.
References
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Journal ArticleDOI

Fluid overload in acute heart failure--re-distribution and other mechanisms beyond fluid accumulation.

TL;DR: This paper elaborate on this possible pathophysiological mechanism of fluid overload, its potential causes and amplifiers, and review its potential Causes and Amplifiers.
Journal ArticleDOI

Early ultrafiltration in patients with decompensated heart failure and diuretic resistance.

TL;DR: In heart failure patients with volume overload and diuretic resistance, ultrafiltration before IV diuretics effectively and safely decreases length of stay and readmissions and clinical benefits persist at three months.
Journal ArticleDOI

Epidemiology of acute heart failure syndromes

TL;DR: The poor, short, and medium term prognosis for acute heart failure is underlined, especially for the most severe patients admitted to an intensive care unit, with in-hospital mortality of 28%.
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