Journal ArticleDOI
Unusually sulfated and oxygenated steroids from Withania somnifera
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TLDR
Four (1, 8-10) and six known withanolides were isolated from the leaves of Withania somnifera and among the new compounds, 10 possessed the rare 3-O-sulfate group with the saturation in A ring and 9 contained unusual 1,4-dien-3-one group.About:
This article is published in Phytochemistry.The article was published on 2005-12-01. It has received 83 citations till now. The article focuses on the topics: Withania somnifera.read more
Citations
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Journal ArticleDOI
Natural withanolides: an overview
Li-Xia Chen,Hao He,Feng Qiu +2 more
TL;DR: This review provides a comprehensive summary of the structural classification and distribution of these new compounds of naturally occurring withanolides.
Journal ArticleDOI
Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts
Sandipan Chatterjee,Shatakshi Srivastava,Asna Khalid,Niharika Singh,Rajender S. Sangwan,O. P. Sidhu,Raja Roy,Chunni Lal Khetrapal,Rakesh Tuli +8 more
TL;DR: In the present study, metabolic profiling of crude extracts of leaf and root of Withania somnifera (Ashwagandha), an important medicinal plant of Indian system of medicine was carried out using NMR and chromatographic techniques.
Journal ArticleDOI
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.
Chandan Mandal,Avijit Dutta,Avijit Dutta,Asish Mallick,Sarmila Chandra,Laxminarain Misra,Rajender S. Sangwan,Chitra Mandal +7 more
TL;DR: Findings suggest that p38MAPK in leukemic cells promotes WA-induced apoptosis, and therefore WA holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin.
Journal ArticleDOI
Withanolides from Withania somnifera roots.
Laxminarain Misra,Priyanka Mishra,Archana Pandey,Rajender S. Sangwan,Neelam S. Sangwan,Rakesh Tuli +5 more
TL;DR: Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-Sitosterol glucoside, stIGmasterol glucose, alpha+beta glucose were isolated from the roots of Withania somnifera for the first time.
Journal ArticleDOI
Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection.
Narayan D. Chaurasiya,G. C. Uniyal,Payare Lal,Laxminarain Misra,Neelam S. Sangwan,Rakesh Tuli,Rajender S. Sangwan +6 more
TL;DR: The developed reversed-phase HPLC method has been applied to the analysis of leaf and root tissues of Withania somnifera for withanolide content and has been validated with respect to various parameters of performance quality.
References
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Book
Progress in the Chemistry of Organic Natural Products
TL;DR: The chemistry and biology of Rocaglamides and related derivatives from Aglaia species (Meliacease) are discussed in detail in a recent paper by.
Journal ArticleDOI
Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.
TL;DR: Investigation of withanolides in the diet may prevent or decrease the growth of tumors in human and show either weak or no activity at 30 microg/mL.
Journal Article
Phytochemical variability in commer- cial herbal products and preparations of Withania somnifera (Ashwagandha)
Rajender S. Sangwan,N. D. Chaurasiya,L. N. Misra,P. Lal,G. C. Uniyal,R. Sharma,N. S. Sangwan,K. A. Suri,Ghulam Nabi Qazi,Rakesh Tuli +9 more
TL;DR: More than 70-fold variation in the daily intake of withaferin A (the main active constituent of Ashwagandha) was found in the products and emphasizes the need for stringent phytochemical standardization of herbal products.