Journal ArticleDOI
Urine analysis in microfluidic devices
TLDR
Advances in microfluidic techniques for urine analysis may improve current routine clinical practices, particularly for point-of-care (POC) applications.Abstract:
Microfluidics has attracted considerable attention since its early development in the 1980s and has experienced rapid growth in the past three decades due to advantages associated with miniaturization, integration and automation. Urine analysis is a common, fast and inexpensive clinical diagnostic tool in health care. In this article, we will be reviewing recent works starting from 2005 to the present for urine analysis using microfluidic devices or systems and to provide in-depth commentary about these techniques. Moreover, commercial strips that are often treated as chips and their readers for urine analysis will also be briefly discussed. We start with an introduction to the physiological significance of various components or measurement standards in urine analysis, followed by a brief introduction to enabling microfluidic technologies. Then, microfluidic devices or systems for sample pretreatments and for sensing urinary macromolecules, micromolecules, as well as multiplexed analysis are reviewed, in this sequence. Moreover, a microfluidic chip for urinary proteome profiling is also discussed, followed by a section discussing commercial products. Finally, the authors' perspectives on microfluidic-based urine analysis are provided. These advancements in microfluidic techniques for urine analysis may improve current routine clinical practices, particularly for point-of-care (POC) applications.read more
Citations
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Point of care diagnostics: Status and future
TL;DR: This chapter discusses the development of personalized medicine and home testing in the developing world, and some of the strategies used to achieve this goal have not yet been developed.
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Modification of microfluidic paper-based devices with silica nanoparticles
Elizabeth Evans,Ellen Flávia Moreira Gabriel,Ellen Flávia Moreira Gabriel,Tomás Enrique Benavidez,Wendell K. T. Coltro,Carlos D. Garcia +5 more
TL;DR: The potential of silica nanoparticles to avoid the washing away effect and improve the color uniformity and intensity in colorimetric bioassays performed on μPADs is demonstrated.
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Microfluidic Sample Preparation for Medical Diagnostics
TL;DR: This review explores the current research on microfluidic methods of sample preparation that are designed to aid diagnosis, and covers a broad spectrum of extraction techniques and designs for various types of samples and analytes.
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Microfluidic sample preparation for diagnostic cytopathology
TL;DR: An overview of the conventional sample preparation processes for cytological diagnosis is presented, and the challenges and opportunities in developing microfluidic devices for the purpose of automating or miniaturizing these processes are discussed.
Journal ArticleDOI
Smartphone-based, sensitive µPAD detection of urinary tract infection and gonorrhea.
TL;DR: A microfluidic paper analytical device was designed and fabricated for evaluating UTI (E. coli) and STD (Neisseria gonorrhoeae) from human urine samples and confirms that proteins were not filtered by μPAD, which is essential for this assay.
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