Journal ArticleDOI
Use of high performance liquid chromatography to measure tetrodotoxin in serum and urine of poisoned patients
TLDR
A simple and reproducible method was developed using solid phase extraction cartridges to clean up serum and urine samples from TTX-poisoned patients, and the subsequent analysis of the samples by high performance liquid chromatography with post-column derivatisation and fluorescence detection.About:
This article is published in Toxicon.The article was published on 2004-10-01. It has received 83 citations till now. The article focuses on the topics: Urine.read more
Citations
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Journal ArticleDOI
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
TL;DR: This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.
Journal ArticleDOI
Neurotoxic marine poisoning
TL;DR: Because there are no antidotes, supportive care, including mechanical ventilation in patients with severe paralysis, is the mainstay of treatment.
Journal ArticleDOI
Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean
Yedidia Bentur,Jalal Ashkar,Yael Lurie,Yishai Levy,Zaher S. Azzam,Moni Litmanovich,Marina Golik,Bella Gurevych,Daniel Golani,Arie Eisenman +9 more
TL;DR: To the best of the knowledge, this is the first case series of tetrodotoxin poisoning reported from the eastern Mediterranean and due to L. sceleratus, a species known to contain tetrodtoxin.
Journal ArticleDOI
First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe.
Paula Rodríguez,Amparo Alfonso,Carmen Vale,Carmen Alfonso,Paulo Vale,Antonio Tellez,Luis M. Botana +6 more
TL;DR: This paper shows for first time the presence and toxicity of TTX and 5,6,11-trideoxyTTX in a trumpet shell collected in the European coasts and the results obtained by mouse bioassay showed that the analogue is much less toxic than TTX.
Journal ArticleDOI
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods
Helle Katrine Knutsen,Jan Alexander,Lars Barregård,Margherita Bignami,Beat Johannes Brüschweiler,Sandra Ceccatelli,Bruce Cottrill,Michael Dinovi,Lutz Edler,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Carlo Nebbia,Isabelle P Oswald,Martin Rose,Alain-Claude Roudot,Tanja Schwerdtle,Christiane Vleminckx,Günter Vollmer,Heather M. Wallace,Nathalie Arnich,Diane Benford,Luis Botana,Barbara Viviani,Davide Arcella,Marco Binaglia,Zsuzsanna Horvath,Hans Steinkellner,Mathijs van Manen,Annette Petersen +29 more
TL;DR: In this paper, the authors derived an acute reference dose (ARfD) of 0.25μg/kg bw for tetrodotoxin (TTX) and its analogues, based on an acute oral study with mice, applying a standard uncertainty factor of 100.
References
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Book
Handbook of Clinical Toxicology of Animal Venoms and Poisons
TL;DR: Venomous and Poisonous animals-A Biologist's View, J. Meier Poisonous and Venomous Animals-The Physician's View; and Clinical Toxicology of Spider Bites and Antivenom Therapy.
Journal ArticleDOI
Tetrodotoxin derivatives in puffer fish.
TL;DR: Analysis of puffer fish tissue extracts by a fluorometric tetrodotoxin analyzer revealed the presence of three tetrodonic acid, 4-epitetrodot toxin and anhydrotetrodOToxin derivatives besides tetrodtoxin, which were isolated and identified on the basis of mass spectral and NMR measurements.
Journal ArticleDOI
Fluorometric Determination of Tetrodotoxin by High Performance Liquid Chromatography
TL;DR: In this paper, the authors used high performance liquid chromatography (HPLC) for the determination of Tetrodotoxin by high performance Liquid Chromatography (LCL) for agricultural and biological applications.
Journal ArticleDOI
Application of immunoaffinity chromatography for detection of tetrodotoxin from urine samples of poisoned patients
TL;DR: The combination of immunoaffinity chromatography with HPLC was very useful in detecting TTX from the urine samples of poisoned patients for diagnosis of TTX-food poisoning.
Journal ArticleDOI
Puffer fish poisoning: a potentially life-threatening condition.
Geoffrey K. Isbister,Julie Son,Frank Wang,Catriona J Maclean,Cindy S.-Y. Lin,Josef Ujma,Corrine R Balit,Brendon Smith,D G Milder,Matthew C. Kiernan +9 more
TL;DR: Symptoms of puffer fish poisoning may include paralysis, respiratory failure, numbness, paraesthesia, nausea and ataxia, and health professionals should be aware of the condition so as to institute early and appropriate management.