Journal ArticleDOI
Using a redox-sensitive phosphorescent probe for optical evaluation of an intracellular redox environment.
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TLDR
A redox-sensitive phosphorescent probe Ir-NO has been developed for evaluating the redox environment in living cells and has been used for optical imaging of the intracellular reducing environment by utilizing confocal laser scanning microscopy and phosphorescence lifetime imaging microscopy.Abstract:
A reducing intracellular environment is necessary for living cells. Here a redox-sensitive phosphorescent probe Ir-NO has been developed for evaluating the redox environment in living cells. Upon addition of reducing molecules, such as glutathione and ascorbic acid, the phosphorescent intensity of the probe is turned on, and the emission lifetime is elongated evidently. Furthermore, this probe has been used for optical imaging of the intracellular reducing environment by utilizing confocal laser scanning microscopy and phosphorescence lifetime imaging microscopy.read more
Citations
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Colorimetric and NIR fluorescence receptors for F− ion detection in aqueous condition and its Live cell imaging
Gujuluva Gangatharan Vinoth Kumar,Mookkandi Palsamy Kesavan,Gandhi Sivaraman,Jegathalaprathaban Rajesh +3 more
TL;DR: In this article, a new kind of colorimetric receptors R1 and R2 for fluoride ions have been synthesized and characterized by various spectral techniques, and live cell imaging experiments with the receptors displayed that these receptors extensively applicable to detect fluoride ions in HeLa cells under physiological conditions.
Journal ArticleDOI
Recent advances of iridium(III) metallophosphors for health-related applications
TL;DR: In this paper, a review article collects the most recent papers on health-related applications by exploiting phosphorescent cyclometalated iridium(III) complexes, and the structure-property relationships of these Ir(III)-complexes are emphasized.
Journal ArticleDOI
Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes
TL;DR: It is demonstrated that Ir1 is a promising theranostic agent that can induce mitophagy and visualize changes in mitochondrial morphology simultaneously and no sign of apoptosis is observed in Ir1- and Ir2-treated cells under the same conditions that an obvious mitophagic response is initiated.
Journal ArticleDOI
Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor.
Madushani Dharmarwardana,André F. Martins,Zhuo Chen,Philip M. Palacios,Chance M. Nowak,Raymond P. Welch,Shaobo Li,Michael A. Luzuriaga,Leonidas Bleris,Brad S. Pierce,A. Dean Sherry,Jeremiah J. Gassensmith +11 more
TL;DR: It is shown TMV-ORCAs do not respond to normal cellular respiration, minimizing the likelihood for background, yet still respond to enzymatically produced superoxide in complicated biological fluids like serum.
Journal ArticleDOI
A time-resolved near-infrared phosphorescent iridium(III) complex for fast and highly specific peroxynitrite detection and bioimaging applications
Yuanyan Li,Yongquan Wu,Luyan Chen,Zeng Hong,Xiaoyong Chen,Weican Lun,Xiaolin Fan,Wai Yeung Wong +7 more
TL;DR: The probe FNO2 showed better selectivity towards ONOO- over other interfering biomolecules, including O2- and ClO-.
References
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