Journal ArticleDOI
Using OWL to model biological knowledge
Robert Stevens,Mikel Egaña Aranguren,Katy Wolstencroft,Ulrike Sattler,Nick Drummond,Matthew Horridge,Alan L. Rector +6 more
TLDR
The disciplines of biology and bioinformatics are used to reveal the requirements of a community that both needs and uses ontologies, and what OWL-DL and its underlying description logic either cannot handle in theory or because of lack of implementation.Abstract:
Much has been written of the facilities for ontology building and reasoning offered for ontologies expressed in the Web Ontology Language (OWL). Less has been written about how the modelling requirements of different areas of interest are met by OWL-DL's underlying model of the world. In this paper we use the disciplines of biology and bioinformatics to reveal the requirements of a community that both needs and uses ontologies. We use a case study of building an ontology of protein phosphatases to show how OWL-DL's model can capture a large proportion of the community's needs. We demonstrate how Ontology Design Patterns (ODPs) can extend inherent limitations of this model. We give examples of relationships between more than two instances; lists and exceptions, and conclude by illustrating what OWL-DL and its underlying description logic either cannot handle in theory or because of lack of implementation. Finally, we present a research agenda that, if fulfilled, would help ensure OWL's wider take up in the life science community.read more
Citations
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“Bioinformatics” 특집을 내면서
TL;DR: Assessment of medical technology in the context of commercialization with Bioentrepreneur course, which addresses many issues unique to biomedical products.
Journal ArticleDOI
OWL 2: The next step for OWL
Bernardo Cuenca Grau,Ian Horrocks,Boris Motik,Bijan Parsia,Peter F. Patel-Schneider,Ulrike Sattler +5 more
TL;DR: It is shown that many aspects of OWL have been thoroughly reengineered in OWL 2, thus producing a robust platform for future development of the language.
Book ChapterDOI
Ontology Design Patterns
Aldo Gangemi,Valentina Presutti +1 more
TL;DR: In this chapter, components called Ontology Design Patterns (OP) are described, and methods that support pattern-based ontology design are described that support explicit documentation of design rationales.
Journal ArticleDOI
Bio-ontologies: current trends and future directions
TL;DR: The current position in ontologies is reviewed and how they have become institutionalized within biomedicine and what benefits it might bring to ontologies and their use within biomedical informatics.
Journal ArticleDOI
Literature mining, ontologies and information visualization for drug repurposing
TL;DR: This work reviews the application of literature mining and ontology modeling and traversal to the area of drug repurposing (DR), which has emerged as a noteworthy alternative to the traditional drug development process in response to the decreased productivity of the biopharmaceutical industry.
References
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Journal ArticleDOI
Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Book
Design Patterns: Elements of Reusable Object-Oriented Software
TL;DR: The book is an introduction to the idea of design patterns in software engineering, and a catalog of twenty-three common patterns, which most experienced OOP designers will find out they've known about patterns all along.
BookDOI
The Description Logic Handbook: Theory, Implementation and Applications
TL;DR: The Description Logic Handbook as mentioned in this paper provides a thorough account of the subject, covering all aspects of research in this field, namely: theory, implementation, and applications, and can also be used for self-study or as a reference for knowledge representation and artificial intelligence courses.
“Bioinformatics” 특집을 내면서
TL;DR: Assessment of medical technology in the context of commercialization with Bioentrepreneur course, which addresses many issues unique to biomedical products.
Book
Common Lisp the Language
TL;DR: This greatly expanded edition of the defacto standard is written by the Vice- Chairman of X3J13 (the ANSI committee responsible for the standardization of Common Lisp) and contains the entire text of the first edition plus six completely new chapters.
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Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more