Journal ArticleDOI
Utility of a simple prognostic stratification based on platelet counts and serum albumin levels in elderly patients with diffuse large B cell lymphoma
Yotaro Ochi,Yasuhiro Kazuma,Nobuhiro Hiramoto,Yuichiro Ono,Satoshi Yoshioka,Noboru Yonetani,Akiko Matsushita,Yukihiro Imai,Hisako Hashimoto,Takayuki Ishikawa +9 more
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TLDR
Platelet count and albumin levels are useful prognostic factors, and their combined use can predict survival, even in elderly patients.Abstract:
Few studies have examined the prognostic impact of blood markers [other than the five factors in the enhanced International Prognostic Index (NCCN-IPI)] in elderly patients with diffuse large B cell lymphoma (DLBCL). We retrospectively analyzed 391 DLBCL patients receiving rituximab plus anthracycline-containing chemotherapy to examine the prognostic impact of simple blood markers. The NCCN-IPI was more accurate for discriminating prognoses than the original IPI. Multivariate analysis identified platelet count (<100,000/μl) and albumin (<3.5 g/dl) levels as significantly associated with lower overall survival (OS), independently of the NCCN-IPI. These parameters stratified patients into three risk groups: platelet–albumin (PA) score low (platelet count ≥100,000/μl, albumin ≥3.5 g/dl, n = 243); intermediate (platelet count <100,000/μl, albumin ≥3.5 g/dl or platelet count ≥100,000/μl, albumin <3.5 g/dl, n = 125); and high (platelet count <100,000/μl, albumin <3.5 g/dl, n = 23). The 5-year OS rates were 81.5, 48.6, and 20.2 %, respectively (p < 0.001). Notably, most patients with a low platelet count (n = 30) were stratified into the high-risk subgroup, suggesting that platelet count was prognostic for high-risk patients with a dismal outcome. In elderly patients (n = 291), the prognostic value of the NCCN-IPI might be diminished because the low-risk category was excluded; however, the PA score was predictive of survival: the 5-year OS rates for PA score low (n = 171), intermediate (n = 101), and high (n = 19) groups were 77.6, 47.9, and 19.0 %, respectively (p < 0.001). Platelet count and albumin levels are useful prognostic factors, and their combined use can predict survival, even in elderly patients.read more
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Clinical impact of prognostic nutritional index in diffuse large B cell lymphoma.
TL;DR: The proposed nomogram supports the clinical impact of cachexia on survival and may contribute to individualized therapy in DLBCL.
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Retrospective analysis of factors affecting clinical outcome following CHOP-based chemotherapy in dogs with primary nodal diffuse large B-cell lymphoma.
TL;DR: Presence of thrombocytopenia, greater age, higher neutrophil count, and higher serum globulin concentration all may be associated with a particularly poor outcome in dogs receiving CHOP-based chemotherapy for DLBCL.
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Pretreatment Hemoglobin as an Independent Prognostic Factor in Primary Central Nervous System Lymphomas.
My Le,Ytel Garcilazo,Maria-José Ibáñez-Juliá,Nadia Younan,Louis Royer-Perron,Marion Benazra,Karima Mokhtari,Caroline Houillier,Khê Hoang-Xuan,Agusti Alentorn +9 more
TL;DR: The presence of anemia was associated with poor prognosis in both cohorts of primary central nervous system lymphoma and the accuracy to predict PCNSL outcome was improved using hemoglobin level.
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Survival and risk factors for mortality in pediatric patients with acute myeloid leukemia in a single reference center in low–middle-income country
Mecneide Mendes Lins,Maria Júlia Gonçalves de Mello,Raul C. Ribeiro,Raul C. Ribeiro,Beatriz de Camargo,Maria de Fátima Pessoa Militão de Albuquerque,Luiz Claudio Santos Thuler +6 more
TL;DR: APL patients had the highest incidence of ED and those with other subtypes had increased relapse risk, and high rates of death in complete remission mainly due to infection were observed.
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Prognostic Value of Platelet Counts in Patients with Metastatic Prostate Cancer Treated with Endocrine Therapy
Kenji Shimodaira,Jun Nakashima,Yoshihiro Nakagami,Yosuke Hirasawa,Takeshi Hashimoto,Naoya Satake,Tatsuo Gondo,Kazunori Namiki,Makoto Ohori,Yoshio Ohno +9 more
TL;DR: It is suggested that PS and platelet count are independent prognostic factors and that a combination of these factors can be used to stratify metastatic prostate cancer patients treated with endocrine therapy according to their DSS risk.
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Journal ArticleDOI
Clinical staging of chronic lymphocytic leukemia.
Kanti R. Rai,Arthur Sawitsky,Eugene P. Cronkite,Arjun D. Chanana,Robert N. Levy,Bernard S. Pasternack +5 more
TL;DR: The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients and sex and age were shown to be poor predictors of survival after adjustment for stage.
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