Journal ArticleDOI
Validated HPLC method for the pharmacokinetic study of oral extended-release cefpodoxime proxetil chitosan-alginate beads in rabbits.
Ali Mujtaba,Kanchan Kohli +1 more
TLDR
The proposed HPLC method was successfully applied to pharmacokinetic study in rabbits for CFP loaded CH-ALG beads and marketed immediate release (IR) tablets and the analyte was found to be stable after a number of stability studies.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2017-05-01. It has received 5 citations till now. The article focuses on the topics: Cefpodoxime Proxetil.read more
Citations
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Journal ArticleDOI
Validated reverse phase HPLC diode array method for the quantification of intact bevacizumab, infliximab and trastuzumab for long-term stability study.
Antonio Martínez-Ortega,Agustín Herrera,Antonio Salmerón-García,José Cabeza,Luis Cuadros-Rodríguez,Natalia Navas +5 more
TL;DR: The method was successfully used to quantify BVZ, INF and TTZ in long-term stability studies performed under hospital conditions of use and they showed great stability regarding quantification during the time of the study.
Journal IssueDOI
Quantitative Analysis of Cephradine using the Modern High-performance Liquid Chromatographic Method
TL;DR: In this paper, the authors used HPLC-UV system with Ion Pac column Zorbax 300-SCX Agilent Column; 5μm, 4.6×250 mm used for analysis for Cephradine in formulations capsules.
Journal ArticleDOI
Comparison of the Robustness of Spectrophotometric Method and High-Performance Liquid Chromatographic Method for the Determination of Pioglitazone in Solid Dosage Form
TL;DR: The analysis of pioglitazone hydrochloride in solid dosage form using the HPLC method shows the results are more sensitive, accurate, validated and economical and can be easily applied to raw materials and finished goods compared to the Spectrophotometer method.
Journal ArticleDOI
Solid-Phase Extraction (SPE) Technique to Quantify Cefdinir in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Md. Tauquir Alam,Md. Ali Mujtaba,Afzal Hussain,Abuzer Ali,Mohd. Imran,Md. Abul Barkat,Sherif A. Abdel-Gawad +6 more
TL;DR: In this paper , a biosensitive analysis method for accurate and rapid quantification of cefdinir (CDR) in human plasma by a liquid chromatography-tandem mass spectrometry technique coupled with electrospray ionization was performed.
Journal ArticleDOI
A Comprehensive Review on Bioanalytical Method Development and Validation for Pharmaceuticals
TL;DR: The review focuses on an overview of the bioanalytical method, development, validation, and the quality of sample preparations.
References
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Journal ArticleDOI
A Review of the Pharmacokinetics of Cefpodoxime Proxetil
TL;DR: As expected for a drug eliminated primarily by renal excretion, the disposition of cefpodoxime is altered in patients with impaired renal function; the half-life increases, while apparent plasma clearance and renal clearance decrease.
Journal ArticleDOI
In vitro and in vivo antibacterial activities of CS-807, a new oral cephalosporin.
TL;DR: Systemic infections in mice caused by various pathogens, including beta-lactamase-producing strains, responded well to therapy with oral doses of CS-807, a new oral prodrug of R-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria.
Journal ArticleDOI
Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist.
TL;DR: Cefpodoxime proxetil was well tolerated without any seriously adverse drug reactions and the total increase in the area under the concentration-time curve (AUC) was dose dependent.
Journal ArticleDOI
Cefpodoxime proxetil: a comprehensive review.
TL;DR: Cefpodoxime proxetil, a relatively new broad-spectrum third-generation cephalosporin, has very good in vitro activity against Enterobacteriaceae, Hemophilus spp.
Journal ArticleDOI
High-performance liquid chromatographic method for the determination of cefpodoxime levels in plasma and sinus mucosa
TL;DR: A selective HPLC method was used to study the diffusion of cefpodoxime in sinus mucosa and found linearity and both between- and within-day reproducibility were assessed.
Related Papers (5)
Highly sensitive and selective high-performance liquid chromatography method for bioequivalence study of cefpodoxime proxetil in rabbit plasma via fluorescence labeling of its active metabolite.
Fluorescence detection of etoposide-loaded nanoparticles by HPLC and pharmacokinetics study
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