Journal ArticleDOI
Validating survivin as a cancer therapeutic target.
Reads0
Chats0
TLDR
In this paper, the identification and validation of translational targets for apoptosis-based cancer therapy has posed a great challenge, and the potential applicability in the clinic has been discussed.Abstract:
Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been learned about the molecular organization of apoptotic pathways and their regulators, but the identification and validation of translational targets for apoptosis-based cancer therapy has posed a great challenge. Survivin is an attractive candidate for cancer therapy, so what is its potential applicability in the clinic?read more
Citations
More filters
Journal ArticleDOI
Apoptosis : a basic biological phenomenon with wide-ranging implications in human disease
Bengt Fadeel,Sten Orrenius +1 more
TL;DR: An increased understanding of the signalling pathways that govern the execution of apoptosis and the subsequent clearance of dying cells may yield novel targets for therapeutic intervention in a wide range of human maladies.
Journal ArticleDOI
Targeting IAP proteins for therapeutic intervention in cancer
Simone Fulda,Domagoj Vucic +1 more
TL;DR: The most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist.
Journal ArticleDOI
Regulation of apoptosis by alternative pre-mRNA splicing.
TL;DR: Modulation of isoform production of cell death proteins via pharmaceutical manipulation of alternative splicing may open up new therapeutic avenues for the treatment of disease.
Journal ArticleDOI
Interleukin-6 Overexpression Induces Pulmonary Hypertension
M. Kathryn Steiner,Olga Syrkina,Narasaish Kolliputi,Eugene J. Mark,Charles A. Hales,Aaron B. Waxman +5 more
TL;DR: It is suggested that IL-6 promotes the development and progression of pulmonary vascular remodeling and PAH through proproliferative antiapoptotic mechanisms.
Journal ArticleDOI
Taxanes, microtubules and chemoresistant breast cancer.
TL;DR: Overexpression of the drug efflux pump MDR-1/P-gp, altered expression of microtubule-associated proteins (MAPs) including tau, stathmin and MAP4 may help to identify those patients who are most at risk of recurrence and those patients most likely to benefit from taxane treatment.
References
More filters
Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Peng Li,Deepak Nijhawan,Imawati Budihardjo,Srinivasa M. Srinivasula,Manzoor Ahmad,Emad S. Alnemri,Xiaodong Wang +6 more
TL;DR: Mutation of the active site of caspase-9 attenuated the activation of cazase-3 and cellular apoptotic response in vivo, indicating that casp enzyme-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.
Journal ArticleDOI
The Bcl2 family: regulators of the cellular life-or-death switch.
Suzanne Cory,Jerry M. Adams +1 more
TL;DR: A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches in tissue homeostasis and cancer.
Journal ArticleDOI
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
TL;DR: The identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway and increases cells' sensitivity to apoptotic stimuli is reported.
Journal ArticleDOI
A novel anti-apoptosis gene, survivin , expressed in cancer and lymphoma
TL;DR: It is suggested that apoptosis inhibition may be a general feature of neoplasia and survivin is identified as a potential new target for apoptosis-based therapy in cancer and lymphoma.