Journal ArticleDOI
Validation of EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)
Raphaèle Seror,Elke Theander,Johan G. Brun,Manel Ramos-Casals,Valeria Valim,Thomas Dörner,Hendrika Bootsma,Athanasios G. Tzioufas,Roser Solans-Laqué,Thomas Mandl,Jacques-Eric Gottenberg,Eric Hachulla,Kathy L. Sivils,Wan-Fai Ng,Anne Laure Fauchais,Stefano Bombardieri,Guido Valesini,Elena Bartoloni,Alain Saraux,Matija Tomšič,Takayuki Sumida,Susumu Nishiyama,Roberto Caporali,Aike A. Kruize,C. Vollenweider,Philippe Ravaud,Claudio Vitali,Xavier Mariette,Simon J Bowman +28 more
Reads0
Chats0
TLDR
The European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI) were validated in a prospective international 6-month duration validation study as mentioned in this paper.Abstract:
Objectives To validate the two recently developed disease activity indexes for assessment of primary Sjogren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjogren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability) were evaluated and compared between scores. Results Of the 395 patients included, 145 (37%) and 251 (64%) had currently active or current or past systemic manifestations, respectively. EULAR scores had higher correlation with the gold standard than other scores (ESSDAI with PhGA: r= 0.59; ESSRPI with PGA: r= 0.70). Correlations between patient and systemic scores were very low (ranging from 0.07 to 0.29). All systemic scores had similar large responsiveness in improved patients. Responsiveness of patient scores was low but was significantly higher for ESSPRI compared with SSI and PROFAD. Reliability was very good for all scores. Conclusions ESSDAI and ESSPRI had good construct validity. All scores were reliable. Systemic scores had a large sensitivity to change in patients whose disease activity improves. Patient scores had a small sensitivity to change, however, significantly better for ESSPRI. Systemic and patient scores poorly correlated, suggesting that they are 2 complementary components that should be both evaluated, but separately.read more
Citations
More filters
Journal ArticleDOI
Sjögren syndrome
Pilar Brito-Zerón,W. Baldini,Hendrika Bootsma,Simon J. Bowman,Roland Jonsson,Xavier Mariette,Kathy L. Sivils,Elke Theander,Athanasios G. Tzioufas,Manuel Ramos-Casals +9 more
TL;DR: Knowledge of SjS has progressed substantially, but this disease is still characterized by sicca symptoms, the systemic involvement of disease, lymphocytic infiltration to exocrine glands, the presence of anti-Ro/SSA and anti-La/SSB autoantibodies and the increased risk of lymphoma in patients with SJS.
Journal ArticleDOI
Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases
TL;DR: This review examines the pharmacokinetics, modes of action and therapeutic properties of the anti-malarial drugs, HCQ and CQ, in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and related conditions, as well as osteoarthritis (OA).
Journal ArticleDOI
EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
Manuel Ramos-Casals,Pilar Brito-Zerón,Stefano Bombardieri,Hendrika Bootsma,Salvatore De Vita,Thomas Dörner,Benjamin A Fisher,Jacques-Eric Gottenberg,Gabriela Hernández-Molina,Agnes Kocher,Belchin Kostov,Aike A. Kruize,Thomas Mandl,Wan-Fai Ng,Soledad Retamozo,Raphaèle Seror,Yehuda Shoenfeld,Antoni Sisó-Almirall,Athanasios G. Tzioufas,Claudio Vitali,Simon J Bowman,Xavier Mariette +21 more
TL;DR: The 2019 EULAR recommendations synthesise current thinking on SjS treatment in a set of overarching principles and recommendations and it is hoped that the current recommendations will be broadly applied in clinical practice and/or serve as a template for national societies to develop local recommendations.
Journal ArticleDOI
Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)
Raphaèle Seror,Raphaèle Seror,Hendrika Bootsma,Alain Saraux,Simon J Bowman,Elke Theander,Johan G. Brun,Gabriel Baron,Véronique Le Guern,Valérie Devauchelle-Pensec,Manel Ramos-Casals,Valeria Valim,Thomas Dörner,Athanasios G. Tzioufas,Jacques-Eric Gottenberg,Roser Solans Laqué,Thomas Mandl,Eric Hachulla,Kathy L. Sivils,Wan-Fai Ng,Anne-Laure Fauchais,Stefano Bombardieri,Roberta Priori,Elena Bartoloni,Vincent Goëb,Sonja Praprotnik,Takayuki Sumida,Sumusu Nishiyama,Roberto Caporali,Aike A. Kruize,C. Vollenweider,Philippe Ravaud,Petra M. Meiners,Pilar Brito-Zerón,Claudio Vitali,Xavier Mariette +35 more
TL;DR: This study determined disease activity levels, PASS and MCII of ESSDAI and ESSPRI, which will help designing future clinical trials in SS and the proposal is to include patients with moderate activity and define response to treatment as an improvement of E SSDAI at least three points.
Journal ArticleDOI
EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide.
Raphaèle Seror,Simon J Bowman,Pilar Brito-Zerón,Elke Theander,Hendrika Bootsma,Athanasios G. Tzioufas,Jacques-Eric Gottenberg,Manel Ramos-Casals,Thomas Dörner,Philippe Ravaud,Claudio Vitali,Xavier Mariette,Karsten Asmussen,Soren Jacobsen,Elena Bartoloni,Roberto Gerli,Johannes W. Bijlsma,Aike A. Kruize,Stefano Bombardieri,Arthur Bookman,Cees Kallenberg,Petra M. Meiners,Johan G Brun,Roland Jonsson,Roberto Caporali,Steven E. Carsons,Salvatore De Vita,Nicoletta Del Papa,Valérie Devauchelle,Alain Saraux,Anne-Laure Fauchais,Jean Sibilia,Eric Hachulla,Gabor G. Illei,David Isenberg,Adrian Jones,Menelaos Manoussakis,Thomas Mandl,Lennart Jacobsson,Frederic Demoulins,Carlomaurizio Montecucco,Wan-Fai Ng,Sumusu Nishiyama,Roald Omdal,Ann Parke,Sonja Praprotnik,Matjia Tomsic,Elizabeth Price,Hal Scofield,Kathy L Sivils,Josef S Smolen,Roser Solans Laqué,Serge Steinfeld,Nurhan Sutcliffe,Takayuki Sumida,Guido Valesini,Valeria Valim,Frederick B Vivino,C. Vollenweider +58 more
TL;DR: A user guide for the ESSDAI is provided, which provides definitions and precisions on the rating of each domain, and includes some minor improvement of the score to integrate advance in knowledge of disease manifestations.
References
More filters
Book
An introduction to the bootstrap
Bradley Efron,Robert Tibshirani +1 more
TL;DR: This article presents bootstrap methods for estimation, using simple arguments, with Minitab macros for implementing these methods, as well as some examples of how these methods could be used for estimation purposes.
Book
Health Measurement Scales: A Practical Guide to Their Development and Use
TL;DR: In this article, the authors propose three basic concepts: devising the items, selecting the items and selecting the responses, from items to scales, reliability and validity of the responses.
Journal ArticleDOI
Measuring agreement in method comparison studies
J M Bland,Douglas G. Altman +1 more
TL;DR: The 95% limits of agreement, estimated by mean difference 1.96 standard deviation of the differences, provide an interval within which 95% of differences between measurements by the two methods are expected to lie.
Journal ArticleDOI
Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
Claudio Vitali,Stefano Bombardieri,Roland Jonsson,Haralampos M. Moutsopoulos,E L Alexander,Steven E. Carsons,Troy E. Daniels,P C Fox,Robert I. Fox,Stuart S. Kassan,S R Pillemer,Norman Talal,M H Weisman +12 more
TL;DR: These classification criteria for Sjögren's syndrome have been re-examined by consensus group members, who have introduced some modifications, more clearly defined the rules for classifying patients with primary or secondary SS, and provided more precise exclusion criteria.
Related Papers (5)
EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren's syndrome
Raphaèle Seror,Philippe Ravaud,Xavier Mariette,Xavier Mariette,Hendrika Bootsma,Elke Theander,Arne Hansen,Manel Ramos-Casals,Thomas Doerner,Stefano Bombardieri,Eric Hachulla,Johan G. Brun,Aike A. Kruize,Sonja Praprotnik,Matija Tomšič,Jacques-Eric Gottenberg,Valérie Devauchelle,Salvatore deVita,C. Vollenweider,Thomas Mandl,Athanasios G. Tzioufas,Steven E. Carsons,Alain Saraux,Nurhan Sutcliffe,Claudio Vitali,Simon J Bowman +25 more
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort
Stephen Shiboski,Caroline H. Shiboski,Lindsey A. Criswell,Alan N. Baer,Stephen Challacombe,Hector Lanfranchi,Morten Schiødt,Hisanori Umehara,Frederick B. Vivino,Yongju Zhao,Yan Dong,Deborah Greenspan,Ana Maria Heidenreich,Pekka Helin,Bruce Kirkham,Kazuko Kitagawa,Genevieve Larkin,Mengtao Li,Thomas M. Lietman,J Lindegaard,Nancy A. McNamara,Kenneth E. Sack,P. J. Shirlaw,Susumu Sugai,C. Vollenweider,John P. Whitcher,Ava J. Wu,S. Zhang,W Zhang,John S. Greenspan,Troy E. Daniels +30 more