S
Simon J. Bowman
Researcher at University Hospitals Birmingham NHS Foundation Trust
Publications - 158
Citations - 5984
Simon J. Bowman is an academic researcher from University Hospitals Birmingham NHS Foundation Trust. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 36, co-authored 136 publications receiving 4523 citations. Previous affiliations of Simon J. Bowman include University of Birmingham & Queen Elizabeth Hospital Birmingham.
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Journal ArticleDOI
Sjögren syndrome
Pilar Brito-Zerón,W. Baldini,Hendrika Bootsma,Simon J. Bowman,Roland Jonsson,Xavier Mariette,Kathy L. Sivils,Elke Theander,Athanasios G. Tzioufas,Manuel Ramos-Casals +9 more
TL;DR: Knowledge of SjS has progressed substantially, but this disease is still characterized by sicca symptoms, the systemic involvement of disease, lymphocytic infiltration to exocrine glands, the presence of anti-Ro/SSA and anti-La/SSB autoantibodies and the increased risk of lymphoma in patients with SJS.
Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Reduction of fatigue in Sjögren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study
Shouvik Dass,Simon J. Bowman,Edward M Vital,Kei Ikeda,Colin T. Pease,John Hamburger,Andrea Richards,Saaeha Rauz,Paul Emery +8 more
TL;DR: This is the first double blind, placebo-controlled, randomised pilot study of the efficacy of rituximab in reducing fatigue in Primary Sjögren syndrome to show benefit.
Journal ArticleDOI
Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome.
N Amft,S. J. Curnow,Dagmar Scheel-Toellner,A Devadas,J Oates,J Crocker,John Hamburger,J. R. Ainsworth,J Mathews,Mike Salmon,Simon J. Bowman,Christopher D. Buckley +11 more
TL;DR: The ectopic expression of BCA-1 on endothelial cells and within GC-like structures, together with the strong expression of SDF-1 (CXCL12) on ductal epithelial cells, is a unique feature of inflamed glands in SS.
Journal ArticleDOI
Estimating the prevalence among Caucasian women of primary Sjögren's syndrome in two general practices in Birmingham, UK.
TL;DR: The data support previous studies suggesting a prevalence of PSS in the community of 0.1–0.6% rather than those suggesting a higher figure.