Journal ArticleDOI
Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder
María Eugenia Hernández,Danelia Mendieta,Daniel Martinez-Fong,Frida Loría,Julia Moreno,Iris Estrada,Rafael Bojalil,Lenin Pavón +7 more
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TLDR
The results suggest that depressed patients only reach a partial reestablishment of HPA axis function after the long-term administration of SSRI.About:
This article is published in European Neuropsychopharmacology.The article was published on 2008-12-01. It has received 122 citations till now. The article focuses on the topics: Major depressive disorder.read more
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression
TL;DR: A biologically plausible, multilevel theory is proposed that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis and may shed light on several important questions including how depression develops, why it frequently recurs, and why it is strongly predicted by early life stress.
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A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
TL;DR: Overall, there were similarities in the pattern of cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction.
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The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis
TL;DR: Overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNFα, but antidepressant treatment did reduce levels of IL-1β and possibly those ofIL-6, which are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects ofinflammatory cytokines on the brain.
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Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression.
TL;DR: Age, samples source and ethnic origins may play a potential role in heterogeneity, and European but not non-European subjects have higher levels difference of sIL-2R, TNF-α and IL-1β between MDD patients and controls.
References
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A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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The inflammatory reflex
TL;DR: The discovery that cholinergic neurons inhibit acute inflammation has qualitatively expanded understanding of how the nervous system modulates immune responses, and the opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems.
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Psychological Stress and Disease
TL;DR: The plausibility of the belief that stress contributes to a variety of disease processes is discussed and the role of stress in 4 major diseases: clinical depression, cardiovascular disease, human immunodeficiency virus/AIDS, and cancer is summarized.
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The corticosteroid receptor hypothesis of depression.
TL;DR: Mouse genetics, allowing for selective inactivation of genes relevant for HPA regulation and molecular pharmacology, dissecting the intracellular cascade of CR signaling, are the most promising future research fields, suited for identifying genes predisposing to depression.
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Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
TL;DR: Plasma IL-6 was significantly higher in obese subjects and demonstrated a highly significant inverse relationship with S(I) (r = -0.71, P < 0.001), while plasma TNF was significantly associated with plasma nonesterified fatty acid levels (r=0.49, P = 0.002).